NASHVILLE, Tenn. – Trying to snap out of the funk he’s been in for three games, Peyton Manning is heading to a town to play a team that could help him do just that.

Tennessee is struggling even more than Manning, the four-time MVP. The Titans (5-7) have gone 10 quarters without an interception and 13 without an offensive touchdown. They have lost five straight, and now here comes Manning, who routinely puts up some of his best performances against them.

The banged-up Colts (6-6) have lost three straight themselves, and Manning said there’s a sense of urgency for both teams heading into tonight’s game. The AFC South has been won only by these two teams, yet Jacksonville leads Indianapolis by a game and Tennessee by two.

“I think it’s about how you respond to it,” Manning said. “I know both teams are coming off of disappointing losses. I think that sometimes a short week might be the best medicine for that. I know both teams are looking forward to playing.”

• Colts safety Bob Sanders will not play again this season after being placed on injured reserve with a torn biceps muscle in his right arm.

DOLPHINS: Chad Pennington is scheduled for shoulder surgery today and said it’s 50-50 whether he’ll retire.

Pennington, who will undergo surgery on his right shoulder for the fourth time, said he’s confident he can fully recover and play again, but he’s unsure whether he should try at age 34 and probably won’t decide for several months.

• Miami placed former Pro Bowl cornerback Al Harris on injured reserve because of a hamstring injury.

CHIEFS: Quarterback Matt Cassel underwent an appendectomy and will return to work this week, the team said.

The Chiefs have not indicated whether they hope to have Cassel available for Sunday’s game at San Diego.

SAINTS: New Orleans placed veteran running back Ladell Betts (neck injury) on injured reserve and added veteran linebacker Kawika Mitchell to the roster.

PACKERS: Left tackle Chad Clifton is recovering from a concussion and cornerback Charles Woodson injured his ankle in practice, Coach Mike McCarthy said.

VIKINGS: Quarterback Brett Favre has a sprained right (throwing) shoulder and is going to wait a few days before he decides about playing against the New York Giants on Sunday.

Favre has started 297 straight regular-season games.

LIONS: The NFL fined defensive lineman Ndamukong Suh $15,000 after he received an unnecessary roughness penalty for a hit on Chicago quarterback Jay Cutler.

Suh said he plans to appeal.

JETS: New York released wide receiver Laveranues Coles a few days after re-signing him and added safety Emanuel Cook to the roster.

BROWNS: Quarterback Colt McCoy still isn’t ready to practice because of an ankle injury that will likely keep him out for a third straight game.