PARIS — Anastasia Pavlyuchenkova knocked out the highest seeded player remaining in the women’s draw at the French Open, beating No. 3 Vera Zvonareva 7-6 (4), 2-6, 6-2 today to earn a spot in the quarterfinals.

Pavlyuchenkova, at 19 the youngest player still in the tournament, won the final five games after being broken early in the third set.

The third-seeded Zvonareva followed No. 1 Caroline Wozniacki and No. 2 Kim Clijsters out of the tournament. They both lost in the third round. Fourth-seeded Victoria Azarenka of Belarus is now the highest seeded player left.

It is only the third time that none of the top three seeded women has reached the quarterfinals at a Grand Slam tournament in the Open era, which began in 1968, and the first time at the French Open. It also happened at Wimbledon in 2008 – when the top four were eliminated by the end of the fourth round – and at the Australian Open in 1997.

Also today:

• Roger Federer set another Grand Slam record, extending his quarterfinal streak at major tournaments to 28 with a 6-3, 6-2, 7-5 victory over Olympic gold medal doubles partner Stanislas Wawrinka.

•  Novak Djokovic maintained his perfect season and stretched his overall winning streak to 43 matches by beating Richard Gasquet of France 6-4, 6-4, 6-2.

“I’m definitely playing the best tennis of my life,” Djokovic said, “and I’m trying to stay focused on each game and we’ll see how far I can go.”

•  Defending champion Francesca Schiavone of Italy beat 10th-seeded Jelena Jankovic of Serbia 6-3, 2-6, 6-4 to return to the quarterfinals.

• Marion Bartoli reached the quarterfinals after Gisela Dulko retired because of a leg injury while trailing 7-5, 1-0.

Zvonareva reached the Wimbledon and U.S. Open finals last year and the Australian Open semifinals in January. She saved two match points in the final game against Pavlyuchenkova before hitting a forehand long on the third.

“Well, that’s, I guess, part of the game. I know what I have to work on and what I have to improve,” said Zvonareva, who saved a match point in the second round before advancing. “Of course when you play less than 50 percent of your potential, it’s very tough to win the fourth round of a Grand Slam.”

For the 14th-seeded Pavlyuchenkova, the result is her best at a Grand Slam tournament. Previously, she reached the fourth round at least year’s U.S. Open.

As the French Open rolls along, both Rafael Nadal and Maria Sharapova seem to be getting better and stronger.

That isn’t really surprising considering they are two of only five players remaining with more than one Grand Slam title. But with that experience comes pressure, and both have been feeling it for years.

“I (am) almost 25, but seems like I am playing for 100 years here on the tour,” Nadal said with a laugh after easily eliminating Croatian wild card Antonio Veic 6-1, 6-3, 6-0 in the third round. “In my opinion, tennis is a very demanding sport mentally and physically.”

Sharapova, who faced little trouble in beating Chan Yung-jan of Taiwan 6-2, 6-3, agreed with that assessment.

“We’ve done this for almost all our lives,” said Sharapova, who turned professional when she was 14, “so we feel like we’re on this sort of hamster carousel and we just keep going.”