NAPLES – Cumberland County sheriff’s deputies say speed and alcohol contributed to two crashes Friday evening that sent three people to the hospital, at least one with life-threatening injuries.

Deputies were called to a hit-and-run crash on Harrison Road in Harrison about 6 p.m. Friday. A 2001 Toyota Camry had collided with a 1996 Ford Ranger. The driver and passenger in the Ranger, Christopher Matthews, 39, of Westbrook and Bruce O’Donal, 38, of Naples, respectively, were treated at the scene for minor injuries.

The Camry later crossed the center line about a mile down Harrison Road in Naples and crashed head-on into a Pontiac Grand Am driven by Catherine R. Carter, 55, of Harrison.

The Camry driver, Shane Faulkingham, 21, of Woburn, Mass., and his passenger, Randall Parker, 20, also of Woburn, had to be extricated from the vehicle and were taken to Bridgton Hospital.

Carter was taken by LifeFlight helicopter to Central Maine Medical Center in Lewiston with life-threatening injuries. Information about her condition was being withheld by the hospital at her family’s request.

Faulkingham was later transferred by medical helicopter to Central Maine Medical Center. Information about his condition is being withheld by the hospital at his family’s request.

The crash remains under investigation.