INDIANAPOLIS — The Colts’ victory over Peyton Manning came at a hefty price.

Andrew Luck lost his favorite target and the Indianapolis locker room lost one of its most revered leaders when Reggie Wayne was diagnosed Monday with a torn anterior cruciate ligament in his right knee that will cost him the rest of the season.

Coach Chuck Pagano and teammates were hoping for the best. Instead, they got the worst possible news, and there’s no doubt Wayne’s absence will hurt the AFC South leaders, who are 5-2 this year.