NEW YORK — A medical examiner ruled Friday that a police officer’s chokehold caused the death of a man whose videotaped arrest and final pleas of “I can’t breathe!” sparked outrage and led to the overhaul of use-of-force training for the nation’s largest police department.

Eric Garner, a black man whose confrontation with a white police officer has prompted calls by the Rev. Al Sharpton for federal prosecution, was killed by neck compressions from the chokehold and “the compression of his chest and prone positioning during physical restraint by police,” city medical examiner spokeswoman Julie Bolcer said.

Asthma, heart disease and obesity were contributing factors in the death of the 43-year-old Garner, a 6-foot-3, 350-pound father of six, she said.

The finding increases the likelihood that the case will be presented to a grand jury to determine whether Officer Daniel Pantaleo, who placed Garner in the chokehold, or any other officers involved in the confrontation will face criminal charges. Pantaleo’s attorney, Stuart London, declined to comment.

Garner’s wife, Esaw Garner, told the Daily News, “Thank God the truth is finally out.”

Mayor Bill de Blasio extended his sympathies to Garner’s family in a statement and pledged to continue repairing the relationship between minority communities and the New York Police Department.

“I’ve said that we would make change, and we will,” he said.

Chokeholds are prohibited by the NYPD, but partial video of the July 17 confrontation shows an officer placing a chokehold on Garner, who was being arrested on suspicion of selling untaxed, loose cigarettes. Garner then apparently loses consciousness.

Word of the medical examiner’s ruling spread Friday among passers-by on the Staten Island street where the police confronted Garner and where candles from a makeshift memorial flicker. Garner’s neighbor Charlene Thomas said the officers involved must be punished.

“They killed somebody,” Thomas said. “Why, because they’re cops, they gotta get away with this?”