MELBOURNE, Australia — Venus Williams tried to rally, winning two games and getting another break-point chance after falling a set and 5-0 behind, before her 16th trip to the Australian Open finished in a first-round loss to Johanna Konta on Tuesday.

The 35-year-old, seven-time major winner trudged off Rod Laver Arena, waving to the crowd on the second day of the tournament following a surprising 6-4, 6-2 loss to the No. 47-ranked Konta, a Sydney-born British player who was making her debut in the main draw at the Australian Open.

Williams had a career comeback last season, winning three titles, finding some consistency after a long struggle with illness and finishing the year in the top 10 for the first time since 2010. She reached the quarterfinals at the Australian and U.S. Opens – the first and last majors of the year.

In 2016, she’s 0-2 after also losing in a warm-up tournament at Auckland, New Zealand.

It was the eighth time she’s lost in the first round of a Grand Slam tournament and the third in Australia, where she reached the quarterfinals in her first appearance in 1998 and lost the final to her youngest sister, Serena, in 2003.

Konta was really going for her groundstrokes in a high-risk, high-reward approach that kept Williams on the defensive.

“When the draw came out and I saw who I was playing I was like `Well, OK, I just hope to stay out there more than an hour,”‘ Konta said.

No. 3 Garbine Muguruza needed exactly an hour to beat Estonian qualifier Anett Kontaveit 6-0, 6-4, No. 11 Timea Bacsinszky advanced over Katerina Siniakova 6-3, 7-5 and No. 15 Madison Keys, a semifinalist last year, had to save set points in the first before beating Zarina Diyas 7-6 (5), 6-1.

No. 21 Ekaterina Makarova, who beat Venus Williams in the first round here in 2014, opened with a 6-3, 6-0 win over Maddison Inglis.

On the men’s side, No. 13 Milos Raonic followed up his win over Roger Federer in the final of the Brisbane International tune-up event with a 6-1, 6-4, 6-4 win over Lucas Pouille, and No. 32 Joao Sousa beat Mikhail Kukushkin 6-3, 6-4, 6-3.