CINCINNATI – J.J. Hardy singled home the tie-breaking run in the 10th inning Thursday night, and the Baltimore Orioles held on for a 2-1 victory and an interleague series win over the Cincinnati Reds.

Hardy fouled off a pair of two-strike pitches before driving in Mark Trumbo from second base with his single off Blake Wood (0-2). The Orioles took 2 of 3 in the series, leaving them 8-4 in interleague play against the Reds.

Three Orioles pitchers limited the Reds to two hits for the second straight night. Cincinnati managed only two singles in a 2-0 loss Wednesday night.

Darren O’Day (1-1) fanned two of the three batters he faced in the ninth. Brad Brach retired the side in the 10th for his second straight save, filling in while closer Zach Britton recovers from a sore forearm.

Left-hander Wade Miley allowed two hits in eight innings, including Joey Votto’s homer in the fourth. Miley matched his career high by striking out 11 for the third time.

AMERICAN LEAGUE

INDIANS 6, TWINS 2: Trevor Bauer struck out seven in 61/3 innings, and Carlos Santana had two doubles and two RBI to lead Cleveland at Minneapolis.

Bauer (1-2) gave up two runs, three hits and three walks, lowering his ERA from 8.44 to 6.35. Andrew Miller pitched 11/3 innings of scoreless relief and the Indians took all three games in a series that included a rainout Wednesday night.

Ervin Santana gave up one run, four hits and three walks over six innings for the Twins, who are 1-5 to start a 10-game homestand.

RAYS 8, TIGERS 1: Steven Souza Jr. came within a single of hitting for the cycle, Erasmo Ramirez and two relievers combined on a five-hitter and Tampa Bay won at St. Petersburg, Florida, for a three-game sweep.

Souza doubled in the first, hit a two-run triple in the second and added a solo homer in the eighth.

Ramirez (2-0) allowed one run and two hits in five innings with five strikeouts and no walks. In the rotation because Jake Odorizzi strained his left hamstring, Ramirez had not started since April 16 last year.

ASTROS 2, ANGELS 1: Carlos Beltran hit his first home run this season and Jake Marisnick also homered to help Houston win at home.

Beltran’s shot came with one out in the first inning off Matt Shoemaker (0-1), and Marisnick’s second homer this season made it 2-0 in the fifth.

Lance McCullers (2-0) scattered three hits and struck out eight over 62/3 scoreless innings as Houston won for the seventh time in eight games. Chris Devenski allowed a home run to Mike Trout starting the ninth and back-to-back singles with one out before striking out Cameron Maybin and Danny Espinosa for his first save.

NATIONAL LEAGUE

NATIONALS 3, BRAVES 2: Ryan Zimmerman hit a two-run homer, Stephen Strasburg struck out 10 and Washington completed a three-game sweep at Atlanta.

A night after they had 14 runs on 20 hits, the Nationals couldn’t solve R.A. Dickey’s knuckleball until Zimmerman homered in the sixth to erase a 2-1 deficit.

Strasburg (2-0) allowed two runs, six hits and two walks in seven innings, winning his first start at SunTrust Park after going 4-3 with a 4.37 ERA in 10 outings at Turner Field. Strasburg improved to 72-8 when the Nationals score at least three runs.

PHILLIES 6, METS 4: Maikel Franco homered and doubled while breaking the longest hitless streak of his career, and Philadelphia won at New York.

Philadelphia took 2 of 3 at Citi Field after losing six straight series to the Mets. New York made seven errors in the series.

Aaron Nola (2-0) labored through five innings, and Hector Neris earned his first save this season.

Noah Syndergaard (1-1) of the Mets struck out 10 in seven innings.