BALTIMORE — Limited to one hit through four innings in Daisuke Matsuzaka’s season debut, the Baltimore Orioles had no reason to believe this would be the game that ended their long offensive drought.

The Orioles set season highs in homers and runs, enjoyed their biggest inning of the year and overpowered the Boston Red Sox 12-9 Saturday night for their first series win.

Ty Wigginton and Matt Wieters homered in a six-run fifth against Matsuzaka, helping Baltimore overcome a 4-1 deficit. Then the Orioles staved off a potential comeback in a game that featured nine home runs – including two apiece by Wigginton and Boston’s David Ortiz.

Baltimore hit five homers, had 12 hits and easily eclipsed its previous high of eight runs. The Orioles came in batting a collective .242 and were last in the AL with 3.2 runs per game.

“It came on a good night because obviously they were swinging the bats, too,” Wigginton said. “Fortunately, we scored more points than they did.”

Matsuzaka (0-1) gave up seven runs, six earned, and seven hits in 42⁄3 innings. He spent all of April on the disabled list with a neck strain.

“I felt OK,” Matsuzaka said. “I think I got a little too greedy, even in this first start. It was an unfortunate waste.”

Wigginton also connected in the sixth against Tim Wakefield, who ended a string of 162 consecutive starts with his first relief appearance since June 9, 2004. Wakefield yielded five runs in 21⁄3 innings.

“I wasn’t very good today,” Wakefield said.

Nick Markakis went 3 for 4 with a homer and five RBI for the Orioles, who also beat the Red Sox on Friday night.

The two-game win streak matches Baltimore’s longest of the season, accomplished once previously.

“We got April behind us, which wasn’t the most pleasant of circumstances,” Orioles Manager Dave Trembley said.

Brad Bergesen (1-2) gave up four runs in five innings for the Orioles, who improved to 3-2 against the Red Sox after going 2-16 against Boston in 2009.

The last time Baltimore won a series from the Red Sox was a two-game sweep May 13-14, 2008.

Ortiz had his 35th career multihomer game, and Jonathan Van Every and Kevin Youkilis also connected for Boston. All three of Ortiz’s homers this season have come against the Orioles.

The Red Sox fell to 11-13, their worst start after 24 games since 1996.

“We’re not playing that well,” Ortiz said. “We have some games that we should have won, but things happened. We’ve got to play better, I guess. All of us. We have to develop a better mentality.”

Matsuzaka took a one-hitter and a 4-1 lead into the fifth before everything unraveled.

“The game was going pretty well,” Boston Manager Terry Francona said.

“Dice was throwing the ball the way he was supposed to, and then we gave up 10 in two innings.”