PORTLAND — Fire damaged a State Street apartment Monday afternoon and sent two tenants to Maine Medical Center for treatment of unspecified injuries.

Smoke alarms went off and tenants reported the fire around 3 p.m. in the 13-unit historic brick house at 264 State St., said Deputy Fire Chief Robert Wassick.

The blaze started in a first-floor apartment, where fire, smoke and water damage was severe, Wassick said. The cause is under investigation.

Wassick said he didn’t know the names or the conditions of the tenants who were taken to the hospital.

Damage to the rest of the building was minimal, and other tenants were expected to return to their apartments Monday evening, he said.

A third-floor tenant, who was unable to use the stairs because of smoke, crawled out a window to a waiting ladder truck and was unharmed, Wassick said.

The building is insured, said Michael Scannell, a Portland resident who owns the house, which was built in 1887 for Charles Tobie.

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