TORONTO – Opening-season trips don’t seem to agree with the Boston Red Sox.

A year after losing their first six games to start the season, the Red Sox finished a 1-5 trip Wednesday with a 3-1 loss to the Toronto Blue Jays.

Additional Photos

Kevin Youkilis of the Red Sox grimaces Wednesday after striking out in the ninth inning with the tying runs in scoring position in a 3-1 loss at Toronto. The catcher is J.P. Arencibia. The Associated Press

“That’s not the road trip we want,” Boston Manager Bobby Valentine said, “but we’ve got a homestand coming up and we’ll try to see if we can’t get things going in the right direction.”

Ricky Romero outdueled Jon Lester and Yunel Escobar drove in two runs for the Blue Jays, who took 2 of 3 from Boston.

“Obviously it’s not the way we wanted to start,” Lester said.

The Red Sox home opener Friday against Tampa Bay can’t arrive soon enough.

“It’s like a reset for everybody,” designated hitter David Ortiz said. “Hopefully we start playing better once we get home.”

Not much has gone right for the Red Sox. And it doesn’t help that everyone remembers how last year ended — with a historic swoon over the final month that cost Boston a wild-card berth.

“We’re not playing good right now,” Lester said. “The games we’ve pitched well we don’t hit, the games we don’t pitch well, we hit. We haven’t put it together right now. Nobody in this clubhouse wants to start slow, regardless of years past.”

Other than a third inning that saw the teams combine for five hits and three runs, left-handers Romero and Lester were perfect until Lester (0-1) issued a two-out walk to Rajai Davis in the eighth, snapping a streak of 15 consecutive outs. Davis stole second, beating the tag on a failed pickoff play, then scored on Escobar’s single to center.

Romero (1-0) saw his streak of 17 straight outs end when Jacoby Ellsbury and Dustin Pedroia drew back-to-back walks to begin the ninth. He left after Adrian Gonzalez flied to center, with both runners advancing.

Sergio Santos came on to strike out Youkilis, then ended it by getting Ortiz to ground out. The save was the first of the season for Santos, who had blown his first two chances.

“There was quite a bit on my mind just because of everything that’s happened,” said Santos, who coughed up the lead in the ninth inning of Monday’s home opener. “It was nice to block all that out, get out there and throw some effective pitches.”

Romero allowed three hits, all singles, in 81/3 innings. He walked two and struck out five.

“Ricky was the story here today,” Blue Jays Manager John Farrell said.

Romero, who won just two of his first 11 career starts against the Red Sox, beat Boston for the third straight time. He earned back-to-back victories over the Red Sox last September, beating them Sept. 8 at Toronto and Sept. 14 at Fenway Park.

“He’s very effective,” Youkilis said. “He’s the ace of that staff for a reason.”

Pedroia called Romero “one of the best lefties in baseball.”

Lester allowed three runs and three hits in eight innings, walked three and struck out six in his seventh career complete game. Lester, who was beaten by Justin Verlander of Detroit on opening day last Thursday, hasn’t won since beating the Blue Jays at Toronto last Sept. 6, a span of six starts.

“You can’t ask for him to throw the ball any better than that,” Pedroia said. “I feel horrible for him.”

Romero set down the first six batters he faced before giving up a run in the top of the third. Cody Ross and Mike Aviles led off with back-to-back singles, but Ross was forced out at third on Kelly Shoppach’s attempted sacrifice. Ellsbury followed with an RBI single to left, but Romero recovered by striking out Pedroia and getting Ortiz to ground out.

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