AMHERST, Mass. — Nicole Dupuis hit a two-run homer in the fifth inning to give fourth-seeded Keene State a 4-2 win Thursday over fifth-seeded St. Joseph’s on the opening day of the NCAA Division III softball regional at Amherst, Mass.

St. Joseph’s (33-8) took a 2-0 lead in the top of the third inning on a two-run homer by Emily Leverone, her 10th of the season. But they managed just four hits off Emily Albin as they dropped into the losers’ bracket of the double-elimination tournament.

Keene State (26-10-1) took advantage of two errors to tie the game in the bottom of the third against Maddie Kluna. Dupuis hit a sacrifice fly after the first run scored on an error.

Dupuis’ fifth-inning home run came after a leadoff single by Sara Stocklinski.

Kluna allowed six hits, struck out eight and walked three.

Rain early Thursday pushed back the start of the tournament, causing Husson and the University of New England to have their openers moved to Friday. Husson (33-11) faces Amherst (34-4), and UNE (26-12) meets SUNY Plattsburgh (31-9).

St. Joseph’s will play an elimination game Friday against Keuka (22-12), a 4-3 loser to SUNY Cortland.