STORRS, Conn. – Kayla McBride scored 21 points and Skylar Diggins added 19 to help No. 5 Notre Dame upset top-ranked Connecticut 73-72 on Saturday in the Big East basketball opener for both teams.

Trailing 73-72 with 6 seconds left, Kaleena Mosqueda-Lewis missed a 3-pointer from the corner and the Irish (12-1, 1-0 Big East) got the ensuing rebound and ran out the clock as Diggins threw the ball into the air at the final buzzer.

The Irish have had the Huskies’ number the past few years, winning five of the past six meetings, including two games in the Final Four over the past two seasons.

Mosqueda-Lewis and Stefanie Dolson each scored 17 points to lead UConn (12-1, 0-1).

The rivalry, which UConn leads 29-9, has grown into one of the biggest in women’s college basketball.

Even with three starters gone from last season’s team, Notre Dame was too much in front of a sellout crowd of 10,167.

UConn had three chances in the final 30 seconds to win the game.

First, Breanna Stewart had her shot blocked in the lane. The Huskies maintained possession and then after a timeout, Stewart missed a jumper from the top of the key. Kelly Faris grabbed the rebound giving UConn one more chance, but Mosqueda-Lewis, wide open, had her 3 fall off the rim.

DEPAUL 86, (11) LOUISVILLE 80: Anna Martin scored 22 points and DePaul held on to upset Louisville at Chicago in the Big East opener for both schools.

Brittany Hrynko had 21 points and seven assists for the Blue Demons (12-3), who have won six in a row.

Louisville (12-3), had won its previous three games.

(14) PURDUE 68, (25) NEBRASKA 66: Sam Ostarello had 17 points and a career-high 19 rebounds as the Boilermakers held off the Cornhuskers (11-4, 1-1) in overtime at Lincoln, Neb.

Purdue (13-2, 2-0 Big Ten) never trailed in the extra period, but Ostarello’s basket with 43 seconds left made it 68-66, Purdue.

(17) OKLAHOMA 78, TEXAS 70: Sharane Campbell scored 24 points as Oklahoma won at Austin, Texas.

Campbell made all three of her 3-point attempts, as did Morgan Hook, who finished with 17 points for the Sooners (12-2, 2-0 Big 12).

Aaryn Ellenberg scored 18 points for Oklahoma, which led by double digits for most of the second half.

Empress Davenport and Chassidy Fussell each had 14 points for Texas (7-6, 0-2).

(21) KANSAS 60, WEST VIRGINIA 59: Carolyn Davis hit a go-ahead layup with 42 seconds remaining as Kansas won at Morgantown, W. Va.