A Portland man was in critical condition Tuesday night after his SUV was struck head-on Monday night on Interstate 295 in South Portland.

Maine State Police said a 2002 Toyota 4Runner driven by Paul Regan, 37, of Dayton was traveling south around 9 p.m. when he lost control and crossed the median. His vehicle went airborne after striking the guardrail and collided head-on with a 2014 Jeep Cherokee on the northbound side of the highway.

The driver of the Jeep, 26-year-old Nicholas Dubose of Portland, suffered a serious head injury and was listed in critical condition Tuesday night at Maine Medical Center in Portland.

Dubose’s passenger, 25-year-old Thomas Netting, and Regan had minor injuries.

The cause of the crash remains under investigation.