NEW YORK — Bryce Harper homered early, then doubled and scored the go-ahead run in the 11th inning Friday night on a bases-loaded walk by Jeurys Familia, sending the Washington Nationals over the New York Mets 4-3 for their fifth straight win.

Familia again had trouble finding the strike zone, forcing home a run with a walk to Trea Turner as the Mets lost for the sixth time in seven games. New York fell to 1-3 in extra innings early this season.

The Nationals, the top-hitting team in the major leagues, hadn’t gotten a hit since Jose Lobaton’s leadoff homer in the fifth when Harper sliced a double to open the 11th.

After Daniel Murphy was intentionally walked by Josh Smoker (0-1), Familia relieved. On Thursday night, Familia – who led the majors with 51 saves last year – made his season debut after a 15-game domestic violence suspension and labored through 30 pitches, walking two.

PHILLIES 4, BRAVES 3: Jeremy Hellickson pitched seven strong innings, and Cesar Hernandez had three hits and scored two runs to lead Philadelphia at home.

Hellickson (3-0) allowed two runs and three hits, with five strikeouts and no walks.

CUBS 6, REDS 5: Anthony Rizzo tied the game with a two-out, three-run homer in the ninth and Kris Bryant hit a sacrifice fly in the 11th inning, rallying Chicago at Cincinnati.

The Cubs won for the 19th time in their last 23 games against the Reds and for the 16th time in their last 20 games at Great American Ball Park.

CARDINALS 6, BREWERS 3: Adam Wainwright homered and drove in four runs while getting his first victory of the season, leading St. Louis at Milwaukee.

Wainwright ripped a two-run homer into the second deck in left field off Wily Peralta (3-1) to put the Cardinals up 2-1 in the third. He drove in two more runs with a single in the fourth to extend the lead to 5-1.

AMERICAN LEAGUE

ASTROS 6, RAYS 3: Carlos Beltran, playing three days before his 40th birthday, led off the second inning with his 423rd home run, and Houston rallied at St. Petersburg, Florida.

Beltran homered off Alex Cobb (1-2) and also singled in the fourth as the Astros won for the ninth time in 11 games. With 1,040 extra-base hits, Beltran is one behind Pete Rose for third among switch hitters, behind Eddie Murray (1,099) and Chipper Jones (1,055).

RANGERS 6, ROYALS 2: Joey Gallo and Robinson Chirinos each homered twice to back a season-high eight innings from Cole Hamels, and Texas won at Arlington, Texas.

Gallo’s first homer was a tiebreaking two-run shot in the second inning on a 3-0 pitch – a liner that matched teammate Carlos Gomez for the longest in the majors this season at 462 feet and was the hardest with an exit velocity of 116 mph.

INDIANS 3, WHITE SOX 0: Corey Kluber pitched a three-hitter and faced two over the minimum, leading Cleveland at Chicago.

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PIRATES 6, YANKEES 3: Josh Bell hit his second home run in as many games and Pittsburgh, at home, got to CC Sabathia early.