HOUSTON — Texans quarterback Deshaun Watson sustained a season-ending knee injury in practice Thursday, two people familiar with the situation told The Associated Press.

The rookie suffered a torn anterior cruciate ligament in one of his knees and will go on injured reserve. The people spoke on the condition of anonymity because the team hadn’t announced the injury.

His injury is the latest blow to a team that lost three-time NFL Defensive Player of the Year J.J. Watt and linebacker Whitney Mercilus to season-ending injuries Oct. 8.

The former Clemson standout had been a bright spot in a challenging season for the Texans (3-4). The 12th overall pick in this year’s draft was the AFC offensive player of the month after throwing for 1,171 yards with 16 touchdowns, and running for 145 yards and another score.

Clemson Coach Dabo Swinney talked about Watson’s injury, and noted that he rebounded from the same injury when he was with the Tigers.

“I talked to Deshaun late this afternoon and we are disappointed,” Swinney said. “But he’s a person who has had some setbacks in his life and always comes back stronger. Since he went through the rehab before, he knows what it takes.”

Watson also tore his ACL in 2014 as a freshman at Clemson.

“All he did after the injury in 2014 was come back and lead us to the national championship game twice and of course we won it last year,” Swinney said. “He started all 30 games the last two years here. I have no doubt he will come back from this. He has the resolve. His work ethic and drive are incredible.”

COLTS: Quarterback Andrew Luck was put on injured reserve, marking the end of his season and the beginning of a different rehab program that officials believe will get their star quarterback on the field next fall.

After having surgery in January for a partially torn labrum in his throwing shoulder, Luck missed all of Indianapolis’ offseason workouts, all of training camp, the entire preseason and now the entire 16-game regular season.

COWBOYS: Running back Ezekiel Elliott has no chance with his latest attempt to delay a six-game suspension for alleged domestic violence, NFL lawyers said.

The lawyers told the 2nd U.S. Circuit Court of Appeals in New York that it should not interfere with Elliott beginning his suspension Sunday when the Cowboys play Kansas City at home because the NFL Players Association “has no likelihood of success on appeal.”

The union has asked the court to block the start of the suspension until it considers its request to overturn a lower-court ruling on the grounds that Elliott’s career will be irreparably harmed if his suspension begins now.

The league said in a written submission that the public, including NFL fans and victims of abuse, have a “strong interest” in seeing that penalties stemming from domestic abuse by NFL players are promptly investigated and discipline is imposed in a timely manner.

BUCCANEERS: Jameis Winston said his injured throwing shoulder is getting better.

The quarterback practiced again, throwing for the second straight day in preparation to face New Orleans.

This is the first time Winston has thrown early in the week since spraining the AC joint in his right shoulder on Oct. 15.

CHIEFS: Linebacker Tamba Hali returned to practice for the first time since the end of last season, though it’s unclear when he will be activated from the physically unable to perform list.

His return begins a three-week window in which the Chiefs must decide whether to activate Hali or shut him down for the season. The 33-year-old Hali missed the offseason program and all of training camp to rest and rehabilitate his ailing knees.

The Chiefs, who visit Dallas on Sunday, could use Hali’s help after losing Dee Ford to a back injury in Monday night’s game against Denver. Ford hasn’t practiced this week.

GIANTS: Joan Tisch, a noted philanthropist and the widow of former team co-owner Bob Tisch, died at 90 after a brief illness.

Giants CEO John Mara called her a “great lady who led an extraordinary life that touched so many people.” He lauded her as an “outstanding role model for her wonderful family and for all of us who knew her.”

THURSDAY’S GAME

JETS 34, BILLS 21: Matt Forte ran for two touchdowns four days after complaining the Jets didn’t run the ball enough, and an overwhelming defense sacked Tyrod Taylor seven times in New York’s win over visiting Buffalo.

Buffalo (5-3) came in having scored 64 points in its last two wins, but self-destructed with turnovers and miscues. New York (4-5), which snapped a three-game slide in which it held leads in each defeat, looked more like the challenger to New England in the AFC East.

Forte scored on runs of 10 and 5 yards and had 14 carries for 77 yards. Augmenting that was Bilal Powell with a 51-yard burst and 74 yards on nine carries. Quarterback Josh McCown got in on the fun with a 10-yard scramble to open the scoring and New York rushed for 194 yards overall.

Jordan Jenkins had two of the Jets’ sacks as they never allowed Buffalo’s offense to get on track.

Indeed, mistakes were the Bills’ trademark.

Buffalo made a key error on New York’s second touchdown drive. Cedric Thornton sacked McCown, but grabbed his face mask. The 15-yard penalty, which followed a 20-yard pass to Jermaine Kearse and a 22-yard run by Forte, led to Robby Anderson beating double coverage for a 25-yard TD reception.

Forte’s 10-yard run made it 24-7 and came one play after Powell broke four tackles on his 51-yard jaunt that featured slick moves and plenty of speed.

The Bills hurt themselves further when Nick O’Leary fumbled on a strange play. The tight end caught Taylor’s third-down pass and fell to the ground untouched. He delayed, heard no whistle, and got up. But the ball then was stripped by rookie safety Marcus Maye and recovered by fellow rookie safety Jamal Adams.

Adding to the miscues, Bills DE Jerry Hughes drew a 15-yard unsportsmanlike conduct penalty for mouthing off to an official – during a timeout, no less – on the ensuing Jets drive.

Taylor also fumbled when sacked for the sixth time, and Forte’s 5-yard TD run followed. And even when the Bills recovered a late onside kick, they were flagged for offside.

New York opened the scoring – the fourth straight game it has led early – after some strong defense pinned Buffalo near its goal line. A punt set up the Jets near midfield and they used eight plays to score.

McCown, looking very spry for a 38-year-old QB, went in untouched down the left side on a scramble for a 7-0 Jets lead.

Buffalo matched that, aided by Taylor’s 18-yard scramble on third down. Rookie Zay Jones caught his first pro TD, an 11-yarder when he got wide open over the middle.

An offensive pass interference call on Austin Sefarian-Jenkins TD catch negated the tight end’s TD early in the second quarter and the Jets settled for Chandler Catanzaro’s 45-yard field goal to retake the lead. He later hit a 32-yarder.

The Jets found a pass rush that was missing in action most of the year. They came in with 11, which was last among teams that had played eight games.

Buffalo scored two late touchdowns to make the final margin less lopsided.