INDIANAPOLIS — Victor Oladipo suffered a serious right knee injury that could alter the season for the Indiana Pacers, who beat the Toronto Raptors 110-106 on Wednesday night.

The All-Star guard crumpled to the ground with 4:05 left in the second quarter as he tried to defend an outlet pass to Toronto’s Pascal Siakam.

The magnitude of the injury was apparent almost immediately. Trainers draped a towel over the leg, and players from both teams surrounded Oladipo as he remained down. No replays were shown on the video screen that stretches from free-throw line to free-throw line.

Fans began chanting his name and gave him a standing ovation as he was carted off on a stretcher. Team officials said Oladipo was scheduled to have an MRI on Thursday.

Oladipo leads the Pacers in scoring at 19.2 points per game, and it appears that Indiana, which is third in the Eastern Conference behind Toronto and Milwaukee, will be without him for a substantial amount of time. He missed 11 games earlier this season because of a sore right knee, and the Pacers went 7-4.

ROCKETS 114, KNICKS 110: James Harden scored a career-high 61 points, tying Kobe Bryant’s record for a visiting opponent at the current Madison Square Garden, and made a clinching layup with 3.8 seconds remaining.

It was Harden’s fifth 50-point game this season. He finished 17 of 38 from the floor. He was only 5 of 20 on 3-pointers but was 22 of 25 from the free-throw line and grabbed 15 rebounds.

CLIPPERS 111, HEAT 99: Tobias Harris scored 22 of his 31 points in the first half, and Los Angeles clamped down on defense in the second half to earn a win at Miami.

Montrezl Harrell scored 14 of his 16 points in the fourth quarter for the Clippers.

NETS 114, MAGIC 110: D’Angelo Russell had 25 points and 10 rebounds, Spencer Dinwiddie scored 29 points, and Brooklyn won at home for its fifth straight victory.

NOTES

GRIZZLIES: Guard Mike Conley said team owner Robert Pera told both he and center Marc Gasol that they will be mentioned in potential trade talks before reports that Memphis will be listening to offers for the NBA’s longest-tenured teammates.

Conley said Pera called him Tuesday to alert him to the Grizzlies’ intentions.

Gasol declined to share details of his conversations with the Grizzlies owner, saying he considers those private. Gasol, who can opt out of his contract this summer, says he had not asked to be traded.

Conley and Gasol are the Grizzlies’ remaining cornerstone players having played their entire careers with Memphis. ESPN.com reported late Tuesday afternoon that the Grizzlies were open to trading the veterans.

Since starting the season 12-5, Memphis has gone 7-23.