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Rams quarterback Matthew Stafford was placed on injured reserve on Saturday. Butch Dill/Associated Press

Quarterback Matthew Stafford was placed on injured reserve by the Los Angeles Rams on Saturday, one day after he cleared the NFL’s concussion protocol for the second time this season.

Stafford already had been ruled out for the Rams’ home game against Seattle on Sunday due to a neck injury. The Super Bowl winner will now be sidelined for at least four games, and his season could be over.

Stafford has missed two of the past three games for the Rams (3-8), whose title defense has fallen apart with a five-game losing streak. Although the Rams haven’t confirmed Stafford had a concussion this season, he made two trips through the league’s concussion protocol.

John Wolford will start at quarterback for Los Angeles against the Seahawks. All-Pro defensive tackle Aaron Donald and All-Pro receiver Cooper Kupp also are out with injuries.

Stafford felt numbness in his legs during the Rams’ loss at New Orleans two weeks ago while playing just two days after clearing the concussion protocol for the first time.

After Stafford cleared the protocol again Friday, Coach Sean McVay acknowledged the struggling Rams likely wouldn’t rush back their 34-year-old star quarterback, who is under contract until 2026.

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JETS: New York activated offensive tackle George Fant from the injured reserve list, in time for its game against the Vikings in Minnesota on Sunday.

Fant missed the last eight games while dealing with a knee injury. He started the first three games this season at left tackle while Duane Brown was injured before being sidelined himself.

Brown has started the last seven games at left tackle since being activated from IR with a shoulder injury and is likely to remain there. Fant, who entered the season projected as the team’s right tackle after the Jets signed Brown, could play there Sunday.

Cedric Ogbuehi, the starter on the right side the last four weeks, was placed on injured reserve after being listed as doubtful with a groin injury and an illness. Rookie Max Mitchell started the first four games at right tackle before injuring a knee. He was activated from IR last week and replaced Ogbuehi after he was hurt in the win against Chicago.

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