LOUISVILLE, Ky. — Darrion Trammell and San Diego State used a dominant defensive performance to knock top overall seed Alabama out of the NCAA Tournament on Friday night, bottling up All-America freshman Brandon Miller in a 71-64 victory in the Sweet 16.

Trammell scored 21 points, while Miller, whose outstanding season was marred by off-the-court complications, was held to nine points on 3-of-19 shooting and had six turnovers.

The fifth-seeded Aztecs (30-6) will face either Creighton on Sunday in the West Region final as they seek their first Final Four in program history. Roughly 30 minutes later, the tournament’s final remaining No. 1 seed, Houston, lost 89-75 to Miami, leaving March Madness without a single top seed among its final eight teams for the first time since seeding began in 1979. The other top seeds, Purdue and Kansas, lost during the tournament’s opening weekend.

San Diego State trailed 48-39 midway through the second half before going on a 12-0 run and controlling the game from there. The Aztecs finished with eight blocked shots – five by Nathan Mensah – and forced 14 turnovers.

The March Madness run of Alabama (31-6) was clouded by its response to the Jan. 15 fatal shooting of a 23-year-old woman in Tuscaloosa, which led to capital murder charges against a then-Crimson Tide player, Darius Miles.

Miller was at the scene of the shooting and has not been charged, but police have said in court documents that Miles texted Miller to bring him his gun. Authorities have said Miller is a cooperating witness, and he did not miss any playing time. Miller has received armed security protection during the tournament.

Mark Sears scored 16 points and Jahvon Quinerly and Charles Bediako each had 10 for Alabama, which shot 32% overall and a miserable 3 of 27 (11.1%) from 3-point range. The Crimson Tide fell short of the second Elite Eight berth in school history.

“Alabama’s a great team. They have a lot of talented players and individuals,” Trammell said. “We knew it was going to be hard. It was a dogfight. Very physical.”

Sears’ layup got Alabama within 66-64 with 46 seconds remaining, but Matt Bradley made two free throws and Micah Parrish followed by making three of four attempts, including two with 17 seconds left.

Jaedon LeDee finished with 12 points for the Aztecs.

San Diego State shot just 38% and was outrebounded 52-48, but the Aztecs made clutch shots to rally after Alabama seemed in control behind a faster pace after halftime. A technical foul on Aztecs Coach Brian Dutcher also seemed to spark his seasoned team, which maintained its physical play and thwarted every attempt by the Tide to rally.

CREIGHTON 86, PRINCETON 75: Creighton used its size, 3-point shooting and a swarming second-half defense to end the March Madness run of Princeton, beating the 15th-seeded Tigers in Louisville, Kentucky.

The sixth-seeded Bluejays (24-12) advanced to their first regional final since they were part of an eight-team NCAA Tournament in 1941.

Ryan Kalkbenner, the two-time Big East defensive player of the year, scored 22 points to lead the Bluejays. Baylor Scheierman made five 3s and finished with 21 points.

The Tigers (23-9) were led by Ryan Langborg with 26 points and Ivy League player of the year Tosan Evbuomwan with 24 points, six rebounds and nine assists.

MIAMI 89, HOUSTON 75: Nijel Pack and his Miami teammates hit shots from near and far against the stingiest defense in the country to beat Houston in the Sweet 16 in Kansas City, Missouri.

Miami (28-7), only the fifth team this season to score at least 70 points against Houston (33-4), will play second-seeded Texas in the Midwest Region final for the chance to go to the Final Four.

The fifth-seeded Hurricanes reached a regional final for the second straight year, just a few hours after Miami’s ninth-seeded women’s team hung on to beat Villanova and advance to the Elite Eight for the first time. Miami and UConn are the only schools with teams remaining in both tournaments.

This is the first time in three years Houston didn’t make it to the Elite Eight.

The Cougars simply couldn’t stop a multifaceted Miami offense, led by Pack’s 3-point shooting. He had season highs of seven 3-pointers on 10 attempts and 26 points.

Isaiah Wong’s mid-range game helped get the Hurricanes out to a fast start, and he finished with 20 points. Jordan Miller hurt the Cougars with his penetration and had 13 points, and Norchad Omier was his usual rugged self under the basket while recording his 16th double-double with 12 points and 13 rebounds.

It resulted in a heartbreaking end for a Cougars team that was in the Sweet 16 for a fourth straight time, had won 15 of its last 16 games, and had the season-long goal of playing in next week’s Final Four in its home city.

Miami Coach Jim Larrañaga, much to his players’ delight, busted out dance moves in the locker room befitting a 73-year-old man harkening to the disco era. Then Wooga Poplar and Joseph Bensley joined him up front for an impromptu line dance.

Larrañaga will seek his first Final Four with Miami and second overall – he took George Mason there as a No. 11 seed in 2006.

Miami used a 16-5 run spanning the halves to go up by double digits, with Omier’s three-point play and Jordan Miller’s short bank-in with the left hand making it 47-36 and forcing Houston Coach Kelvin Sampson to call timeout less than two minutes into the second half.

Houston battled back to make it a two-point game, but then Pack made three 3s and Miller and Poplar hit one each to fuel a 16-2 run that put the Canes ahead 70-53. The lead grew to as much as 17 points, and Houston never got closer than 11 the rest of the way.

There was no denying it was Miami’s night after Houston made a mini run with under five minutes to play. With the shot clock running down, Omier was forced to put up a jumper just inside the free-throw line. It bounced off the front of the rim, then the backboard, then the front of the rim again before dropping through. A minute later, Houston’s Jarace Walker missed from point-blank range.

Walker led the Cougars with 16 points. Jamal Shead added 15 and All-American Marcus Sasser and Tramon Mark had 14 apiece for the Cougars, who shot just 37% overall and 29% from distance.

Houston found itself behind at halftime for the second straight game after the Hurricanes played their sharpest half of the tournament.

Miami turned the ball over just once in the first 20 minutes, converted Miami’s six turnovers into 15 points and shot 6 of 14 from distance against the second-best 3-point defense in the country.

Pack made four 3-pointers, and all were timely. His first three gave Miami leads, and his fourth broke a 31-31 tie.

TEXAS 83, XAVIER 71: Tyrese Hunter scored 19 points, Marcus Carr and Christian Bishop added 18 apiece, and second-seeded Texas rolled over No. 3 seed Xavier to reach the Elite Eight for the first time in 15 years.

Playing most of the way without ailing star Dylan Disu, the Longhorns – the highest seed left – built a 42-25 lead by halftime. They quickly pushed it past 20 before cruising the rest of the way.

Sir’Jabari Rice had 16 points and Timmy Allen added 11 for the Longhorns (29-8), who kept Souley Boum and the rest of Xavier’s perimeter threats in check while making life miserable for Jack Nunge down low.

Adam Kunkel hit five 3-pointers and led the Musketeers (27-10) with 21 points.

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