SANTA CLARA, Calif. (AP) — Richard Sherman offered one final challenge to San Francisco: “I told their sideline if they threw it my way I’d end the game.”

He did exactly that — just like last time.

Sherman provided the moment of the game against the 49ers once again, a mere 10 months after his touchdown-saving deflection in the NFC championship that sent the Seattle Seahawks to the Super Bowl.

Sherman set up the only touchdown with another key defensive play in this heated rivalry, then made a second interception with the 49ers driving late, and the Seahawks ended a five-game losing streak on San Francisco’s home field with a 19-3 win Thursday night.

“The second one was pretty entertaining. I was laughing the whole time,” Sherman said. “They threw it. I said, ‘Way to be, way to be.’”

The brash cornerback offered plenty without opening his mouth, too: Blowing kisses to the crowd, then putting a finger to his lips to make the hush sign before waving goodbye.

Steven Hauschka kicked four field goals and the Seahawks’ stout defense held Colin Kaepernick and Michael Crabtree in check as Seattle (8-4) overcame 14 penalties for 105 yards, including an offensive pass interference that negated a touchdown.

Russell Wilson passed for 236 yards and thoroughly outplayed Kaepernick, who had one of his worst performances for the 49ers (7-5) in a game with high stakes for the teams’ playoff hopes. And they play again in 17 days.

“My team’s all together, we are buddies. It’s a hard thing to do, winning on their turf,” Wilson said. “The NFC is not easy to win against. We are excited about that opportunity.”

After his second pick, Sherman looked at those fans still remaining in half-empty stadium on a Thanksgiving night and waved. The Seahawks won by the identical score they beat first-place Arizona five days earlier.

Kaepernick was 16 for 29 for 121 yards and the 49ers were outgained 379-164.

Sherman and Crabtree were at the center of the decisive play in January’s NFC title game, when Sherman deflected a pass headed his way in the end zone and Malcolm Smith intercepted it with less than a minute remaining to seal the Seahawks’ 23-17 victory. Sherman later called Crabtree “mediocre.”

San Francisco’s offense might have earned that distinction after its latest dud snapped the Niners’ three-game winning streak.

When the word mediocre came up, Sherman said that distinction went to “their fans” for vulgar name-calling throughout the game.

“You never have to resort to name-calling,” said Sherman, who said a bottle was thrown as the Seahawks exited.

Asked about Crabtree on Thursday, Sherman smiled and quipped: “History? What history?”

“He said he was throwing to the open man. He didn’t care who was out there,” Sherman said about Kaepernick. “I was the open man.”

In the waning moments with thousands of red seats already empty, 49ers CEO Jed York posted on Twitter: “Thank you (hashtag) 49ersfaithful for coming out strong tonight. This performance wasn’t acceptable. I apologize for that.”

The 49ers were held to three points or fewer for the first time since a 29-3 Week 2 loss at Seattle last year.

“We only had three points. We have to start early and we have to play,” Crabtree said. “That’s all we have to talk about.”

Seattle sure looked comfortable in its first trip to new $1.3 billion Levi’s Stadium. It helped that the Seahawks quieted a relatively subdued home crowd.

Sherman got things started when he intercepted Kaepernick’s deep third-down pass on the right sideline in the first quarter to help set up Wilson’s 13-yard touchdown pass to Robert Turbin. A wideopen Turbin easily took the ball down the left sideline on a pretty catch-and-run before beating cornerback Chris Culliver into the end zone.

Hauschka kicked field goals of 21, 36, 35 and 46 yards.

Phil Dawson provided San Francisco’s lone points on a 40-yard field goal late in the third.

Sherman had the fourth twointerception game of his career with his 22nd and 23rd picks since 2011, most in the NFL. It was 49ers coach Jim Harbaugh who turned him into a defensive back at Stanford.

Sherman nearly had another late in the first half, when Seattle outgained San Francisco 202-71. The 49ers were held to 23 yards rushing and shut out in the first half for the first time this season.

“We’ve got to reboot, come back and win them all,” Harbaugh said.

In a lighthearted moment before kickoff, Harbaugh’s black hat blew off during the national anthem and landed on the lowest white stripe of a flag that covered the entire field. A San Francisco staffer quickly retrieved the cap just in time as the flag was being rolled up.

NOTES: Wilson had a 118.8 passer rating to Kaepernick’s 36.7. … Crabtree hurt his left knee 56 seconds into the game after landing awkwardly on his left side following a 5-yard reception on which he was tackled by S Kam Chancellor. … 49ers DT Ray McDonald injured a finger.

Eagles 33, Cowboys 10

ARLINGTON, Texas (AP) — LeSean McCoy threw open his arms just before crossing the goal line on a touchdown run that essentially put away another big win over the Dallas Cowboys.

While Philadelphia didn’t walk off with a playoff berth in hand after beating the Cowboys 33-10 on Thursday, it was a sweet Thanksgiving for McCoy, Mark Sanchez and the Eagles.

McCoy ran for 159 yards and a touchdown, Sanchez had his first scoring run in almost three years and the Eagles rolled in a matchup of NFC East co-leaders on the field where McCoy clinched last season’s rushing title and Philadelphia won a playoffs-or-bust finale.

“This really felt like last year,” said McCoy, who had a season-high 25 carries. “It really did.”

Tony Romo wasn’t around for that game because he was two days removed from back surgery. This time he was trying to play a quick turnaround for the first time, and after yet another back injury. He looked ragged as the Cowboys (8-4) lost their third straight home game.

“It was definitely short just from the Sunday night coming to here,” said Romo, who threw two interceptions without a touchdown, snapping a streak of 38 straight games with at least one TD toss. “I don’t really think that had much to do with the outcome of the game. I think they just played better than us.”

The Eagles (9-3) opened with quick drives of 80 and 88 yards for touchdowns. They took sole possession of the division lead with four games remaining, including a rematch in less than three weeks.

“We’re not into statements,” Eagles coach Chip Kelly said. “We’ve given ourselves the opportunity to play meaningful football in December, and in this league, every week is a whole different deal, a whole different animal.”

McCoy, who led the NFL with 1,604 yards last season, had his fourth 100-yard game in the past seven after going without one the first five weeks and secured his fourth 1,000-yard season since 2010.

Although his deficit to Dallas’ DeMarco Murray in the rushing race is probably insurmountable, McCoy outgained Murray, who was held under 100 yards for just the second time this season.

Murray finished with 73 yards and Dallas’ only touchdown on 20 carries, the last a 6-yard loss when he was dropped by Mychal Kendricks on fourth-and-1 early in the fourth quarter.

“I don’t really compare myself,” McCoy said. “I just try to be me. I don’t really get into that whole, especially during the season, ‘Who’s this. Who’s that’ thing. In the big picture, we’re trying to win games.”

Making his fourth start since Nick Foles was sidelined by a broken collarbone, Sanchez was 9 of 11 for 99 yards in the first quarter. That included a 27- yard scoring pass to Jordan Matthews when Sanchez hit the rookie in stride on a crossing route for a 14-0 lead.

Sanchez finished 20 of 29 for 217 yards with a touchdown and no interceptions two years after he was the starter for the New York Jets and infamously ran into the back side of one of his offensive linemen for a fumble that New England returned for a touchdown in a 49-19 Thanksgiving rout.

“It is like my favorite holiday, so that’s not cool,” Sanchez said. “It was a bummer. The game plan was to try not to do that. And we accomplished that.”

This time, had his first scoring run since Dec. 24, 2011, with the Jets — a 2- yarder after faking the handoff to McCoy in the zone read. McCoy set up the game’s first touchdown with a 38-yard run..

Murray had room to run at times but couldn’t break one longer than 9 yards. Romo had plenty of time early in the game, but one time in the first half tossed a third-down pass to nobody in particular, giving the ball back to the Eagles when the Cowboys were having trouble stopping them.

“We didn’t respond as well as we needed to when we were on offense,” Cowboys coach Jason Garrett said. “We were never able to kind of keep ourselves in this game and certainly that’s a disappointment.”

Lions 34, Bears 17

DETROIT (AP) — After a week of questions about his limited production of late, Calvin Johnson lifted Detroit’s offense with an emphatic reminder that he’s still one of the game’s most dynamic players.

Johnson caught 11 passes for 146 yards with a pair of first-half touchdowns, and the Lions boosted their postseason hopes with a 34- 17 victory over the Chicago Bears on Thursday. Johnson had been held under 60 yards in two of three games since returning from an ankle injury, and there were rumblings that the 29-yearold receiver was slowing down, but he quieted a lot of those concerns with perhaps his best game of the season.

“Guys still believe in what we got going here,” Johnson said. “We had a good week of practice — it was a very short week, but we were very detailed in what we did on the field, coaches taking care of us. It’s our part to come out here and do our job on the field.”

After losing at Arizona and New England and falling out of first place in the NFC North, the Lions (8- 4) spotted Chicago a 14-3 first-quarter lead before rallying with relative ease in the second. Detroit finished with a season-high 474 yards in its highest-scoring game since a 35-14 victory over the New York Giants in its opener.

Joique Bell ran for two touchdowns for the Lions, and Jay Cutler threw two TD passes for Chicago (5-7). Detroit’s Matthew Stafford went 34 of 45 for 390 yards with the two touchdown passes to Johnson.

The Lions have now won back-to-back games on Thanksgiving after losing their previous nine. They beat Green Bay 40-10 last year.

That victory over the Packers was Detroit’s only win in its final seven games last season as the Lions frittered away a playoff spot. They are again in mix for the postseason this year, and Thursday’s game was their first of three in a row at home — all against teams with losing records.

“Every single week there’s a new challenge. We have a new one next week,” Lions coach Jim Caldwell said. “The minute you get comfortable at any stage in our league you’re going to have problems.”

Detroit came in with the league’s top-ranked run defense, and Chicago barely even tried to test it. Matt Forte was a non-factor on the ground, finishing with 6 yards on five carries. Cutler went 31 of 48 for 280 yards with two fourth-quarter interceptions.

Chicago’s imbalanced game plan came only a few days after New England relied heavily on the pass in its victory over the Lions last weekend.