
Pablo Sandoval homered for the second straight day for Boston, hitting a solo shot before leaving the game with a sore neck. He also had a two-run single.
The Red Sox have won the opener of each of their seven series this season.
Russell Martin had a tworun double and rookie Devon Travis belted his sixth homer for the Blue Jays, who were coming off a three-game sweep against Tampa Bay on the first leg of their 10-game road trip.
With one out in the bottom of the ninth, Xander Bogaerts and Ryan Hanigan singled off Miguel Castro (0- 2) before moving up on a wild pitch. Betts then singled through a drawn-in infield — to the left of shortstop Jose Reyes.
Koji Uehara (2-1) worked a perfect ninth for the win.
Trailing 5-4 in the eighth, the Red Sox loaded the bases and David Ortiz was walked intentionally before Hanley Ramirez hit a tying sacrifice fly. Left fielder Dalton Pompey saved at least one run with a diving grab in the gap. Third baseman Josh Donaldson ended the inning by making a leaping grab of Daniel Nava’s liner.
Toronto starter Aaron Sanchez allowed four runs, three earned, and struck out seven in 5 2-3 innings.
Boston’s Joe Kelly struck out 10 in six innings, but gave up five runs and five hits.
The Blue Jays jumped ahead 3-0 in the first on an RBI single by Travis and two-run double by Martin.
Boston got two back in the bottom of the inning on Sandoval’s two-run single.
Travis homered into the Green Monster seats in the third, making it 4-2. Kevin Pillar added an RBI single.
Sandoval homered into Toronto’s bullpen in the fifth.
The start of the game was delayed 33 minutes by rain.
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