PATRIOTS (3-1) at BROWNS (0-4), 1 p.m.

Outlook: Tom Brady! The return of New England’s superstar quarterback following a four-game suspension is the overarching headline in the NFL. Will he be rusty? I doubt it. I also think Rob Gronkowski will bust out of his blocker/decoy role with a day to reward the patience of his fantasy owners. Cleveland is the league’s only winless team but is capable of a competitive game at home, especially if RB Isaiah Crowell (332 yards in the last three games) keeps on the hotfoot.

Television: CBS

Prediction: Patriots, 24-17

BEARS (1-3) at COLTS (1-3), 1 p.m.

Outlook: Two disappointing teams and part of the NFL’s epidemic of 1-3 records as a bad Chicago offense seeks life against a bad Indy defense. Brian Hoyer is expected to make his second consecutive QB start for Chicago, but he’s without WR Kevin White. The Colts are 18-7 following a loss under embattled coach Chuck Pagano, and Andrew Luck has seven TDs and a 104.4 rating in his last three home games, so let’s make it a venue pick.

Prediction: Colts, 27-20

TITANS (1-3) at DOLPHINS (1-3), 1 p.m.

Outlook: Ryan Tannehill and Marcus Mariota both have five interceptions, so whichever mistake-prone QB plays the cleanest game likely will win. Mariota has been solid away, with 12 TDs and a 98.5 rating in eight career road starts. The Dolphins have had extra time to prepare after playing last Thursday night, only increasing the onus to play better at they begin a crucial four-game homestand.

Prediction: Dolphins, 24-20

EAGLES (3-0) at LIONS (1-3), 1 p.m.

Outlook: The Lions beat Philly in Detroit last Thanksgiving, 45-14. And aren’t the upstart Eagles due for a loss? Isn’t perfect rookie Carson Wentz due for a mistake? Maybe on both. But I still have to like Philly, coming off a bye, especially welcoming back key offensive pieces in RB Ryan Mathews and TE Zach Ertz. Matthew Stafford will get his numbers, as usual, but he has little run support or defensive help.

Prediction: Eagles, 31-21

WASHINGTON (2-2) at RAVENS (3-1), 1 p.m.

Outlook: Both teams are on the periphery of playoff-worthy, but only one has a stout defense (Baltimore), while the other is shaky there, especially against the run.

Prediction: Ravens, 23-20

TEXANS (3-1) at VIKINGS (4-0), 1 p.m.

Outlook: The Vikings lose Teddy Bridgewater and Adrian Peterson, the Texans lose J.J. Watt, and yet here they sit, a combined 7-1. Impressive! Minnesota is 4-0 for the first time since 2009 thanks to a big-time defense with 11 takeaways. But Houston’s pass defense could be a challenge to Sam Bradford. Make it a venue pick.

Prediction: Vikings, 21-17

JETS (1-3) at STEELERS (3-1), 1 p.m.

Outlook: Ben Roethlisberger has 18 TD passes in his last five home games, and Antonio Brown has 59 catches for 833 yards and eight scores in his last six at home. And Le’Veon Bell burst off suspension with a rust-free 144 yards last week. Did I mention New York has a disappointing pass defense and that Darrelle Revis is iffy to play?

Prediction: Steelers, 41-17

FALCONS (3-1) at BRONCOS (4-0), 4:05 p.m.

Outlook: We have a humming Falcons pass offense against an elite Broncos pass defense. Within that we have Julio Jones, off a 300-yard receiving game, defended by top corner Aqib Talib. Sweet! Broncos QB Trevor Siemian should play despite a sore non-throwing shoulder, but it’ll be Denver’s defense that swings this game.

Television: FOX

Prediction: Broncos, 27-23

BENGALS (2-2) at COWBOYS (3-1), 4:25 p.m.

Outlook: The Bengals offense gets a sizable boost with the expected season debut of tight end Tyler Eifert, and Cincinnati’s stout defensive front could pose a serious challenge to Dallas’ workhorse rookie back, Ezekiel Elliott. But the Cowboys are too good a team to be a home underdog.

Television: CBS

Prediction: Cowboys, 24-23

BILLS (2-2) at RAMS (3-1), 4:25 p.m.

Outlook: A surprisingly interesting matchup of surging teams whose strong defenses make up for sputtering offenses. The Rams have won three in a row, while the Bills have won two in a row, impressively over Arizona and New England. There also is an erratic quality to both squads, so admittedly our confidence in this pick isn’t great.

Prediction: Bills, 19-17

CHARGERS (1-3) at RAIDERS (3-1), 4:25 p.m.

Outlook: Philip Rivers is 14-6 against Oakland, but the Raiders swept last year. The Chargers blow leads as if that’s the point, while the Raiders are finally learning how to win. The difference here? Derek Carr and Amari Cooper vs. a Chargers secondary beset by injuries.

Prediction: Raiders, 34-31

GIANTS (2-2) at PACKERS (2-1), 8:30 p.m.

Outlook: Aaron Rodgers against Eli Manning will fill a marquee pretty well. Manning is two TD passes shy of being the eighth to reach 300. But little in the NFL is closer to a sure thing than Rodgers at Lambeau. The Packers are coming off a bye, too, while New York is off a short week. One hesitation, though: the Giants won the last meeting in 2013, and won a playoff game at Green Bay in 2011.

Television: NBC

Prediction: Packers, 28-20

MONDAY

BUCCANEERS (1-3) at PANTHERS (1-3), 8:30 p.m.

Outlook: Panthers QB Cam Newton has been in the NFL’s concussion protocol and it appears increasingly likely Derek Anderson will start. That’s a huge dropoff, but I still like the Panthers at home. Carolina has been a huge disappointment and its defense was embarrassed by the Falcons last week, but I see a prideful bounce-back effort.

Television: ESPN

Prediction: Panthers, 30-20

By Greg Cote, Miami Herald (Last week 8-7, season 39-24)