BALTIMORE — Trey Mancini and Jonathan Schoop homered in succession off knuckleballer Steven Wright, Jayson Aquino won his first big league start and the Baltimore Orioles beat the Boston Red Sox 4-2 Saturday night for their fourth straight victory.

Baltimore will seek to complete a three-game sweep on Sunday. The Orioles have not lost a series this year and own the best record in the majors (12-4).

Aquino allowed two runs and six hits over six innings. The 24-year-old lefty previously pitched three times in relief, all last year.

Mychal Givens followed with two perfect innings, Donnie Hart got two outs in the ninth, and Darren O’Day finished for his first save.

Wright (1-2) gave up four runs and nine hits in 3 2/3 innings. Just 10 days earlier, the right-hander got only four outs and yielded eight runs against Baltimore at Fenway Park.

Jackie Bradley Jr. put the Red Sox up 2-0 in the third inning with his first home run, a shot onto Eutaw Street beyond the right-field scoreboard. Boston came in with only seven home runs, fewest in the big leagues.

Limited to three singles over the first three innings, Baltimore hit two singles, two doubles and two homers in a four-run fourth.

Chris Davis doubled and Mancini and Schoop homered before Adam Jones chased Wright with an RBI single.

It was Mancini’s team-high fifth homer of the year. He has eight homers in 17 big league games over two seasons.

ONE DAY LATER, Red Sox Manager John Farrell was still sore about Manny Machado’s spikes-up slide that injured second baseman Dustin Pedroia.

Pedroia was not in Boston’s starting lineup Saturday after hurting his knee and ankle in the eighth inning of Friday night’s 2-0 loss to Baltimore. The injury occurred when Machado spiked Pedroia in the back of his left leg while sliding into second on a force play.

“My knee’s sore, and then my ankle is a little sore, but I’ll be all right,” Pedroia said. “If I have to go in the game, I’d go in the game.”

Farrell was so angered over Machado’s action that he called the league office, seeking clarification about the rule designed to protect infielders from late and aggressive slides.

“Clearly there is a difference in opinion in how that rule was interpreted and the slide,” Farrell said. “Bottom line, if that slide last night is not deemed an illegal slide, we should just get rid of the rule.”

Pedroia said Machado sent him a text after the game, offering an apology.

“I just said, ‘Thanks for reaching out,’ ” said Pedroia.

Pedroia didn’t seem to harbor any hard feelings.

“It’s baseball,” he said. “I was trying to get one out, so I just put my foot on the back part of the base to get that out. If he just slid into the part of the base that I gave him, he’d have been safe. Luckily, he didn’t. We got the out.”