JACKSONVILLE, Fla.

The Jacksonville Jaguars are returning to the playoffs for the first time in a decade thanks to a 45-7 drubbing of rival Houston on Sunday.

Once the NFL’s poster child for futility and a punchline for potential relocation, the Jaguars (10-4) are now one of the league’s top turnaround stories.

Blake Bortles threw three touchdowns passes, including two to a reserve receiver who slept in his car earlier this season. The Jaguars won for the seventh time in eight games to clinch a postseason berth for the first time since 2007.

Bortles finished with a season-high 326 yards and the best QB rating (143.8) of his career, including 186 yards and a touchdown to rookie Keelan Cole. Primary punt returner Jaydon Mickens, who stepped in for injured starter Marqise Lee in the first quarter, caught four passes for 61 yards and two scores against the Texans (4-10).

The Jaguars were an NFL-worst 22-74 over the previous six years, more a laughingstock than a postseason contender.

49ers 25, Titans 23

SANTA CLARA, Calif. (AP) — Jimmy Garoppolo led one final scoring drive in the closing seconds to cap a fantastic first home start and Robbie Gould kicked a winning 45-yard field goal as time expired.

Garoppolo threw for a career-high 381 yards and a touchdown to give the 49ers (4-10) a three-game winning streak in a lost season. And Tom Brady’s former backup showed he could do it at home as well as on the road — and against a playoff contender, no less — outdueling Marcus Mariota down the stretch as the teams traded field goals.

Rams 42, Seahawks 7

SEATTLE (AP) — Todd Gurley rushed for 152 yards and scored four total touchdowns in just 2? quarters, and the Rams moved to the cusp of their first division title since 2003.

The matchup to determine first place in the NFC West was completely one-sided. Los Angeles (10-4) was dominant, embarrassing Seattle into the worst loss during Pete Carroll’s eight seasons in charge.

Taking advantage of field position, the Rams scored on six of seven first-half drives, including a 21-point blitz in the second quarter capped by a 57-yard TD run by Gurley on third-and-20 with less than a minute remaining in the first half to take a 34-0 lead at the break.

Gurley had 144 yards rushing in the first half, twice scoring from the 1. He added a 14-yard TD reception midway through the third quarter for a 40-0 Rams lead and spent the rest of his day watching. The 152 yards rushing were the second best of his career.

The Rams don’t have the division wrapped up, but have a two-game lead with two weeks to play. A win against either Tennessee or San Francisco is enough for their first division title in 14 years.

Vikings 34, Bengals 7

MINNEAPOLIS (AP) — Eric Kendricks had an interception return for a touchdown, Case Keenum passed for 236 yards and two scores, and the Vikings clinched the NFC North over the depleted and disinterested Bengals.

Running backs Latavius Murray and Jerick McKinnon combined for 37 touches and 242 yards from scrimmage for the Vikings (11-3), who were given quite the reprieve on the schedule a week after their eight-game winning streak ended at Carolina in the last of three consecutive road trips. They were never challenged the Bengals (5-9), missing more than half of the starting defense to injuries, and met with a morning report by ESPN that head coach Marvin Lewis will not return next season .

Eagles 34, Giants 29

EAST RUTHERFORD, N.J. (AP) — Nick Foles threw four touchdown passes in his first start replacing the injured Carson Wentz, and the Eagles secured a firstround playoff bye.

Foles hit 24 of 38 passes for 237 yards and no interceptions. The NFC East champion Eagles (12-2) made a late stand on first-and-goal in the final minute in edging the Giants (2-12) for the second time this season, spoiling a three-touchdown, season high 434-yard passing game by Eli Manning.

Foles hit Alshon Jeffery, Zach Ertz, Trey Burton and Nelson Agholor on scoring passes ranging from 3 to 13 yards in filling in for Wentz, who tore an ACL last week and was lost for the season after a brilliant year.

Panthers 31, Packers 24

CHARLOTTE, N.C. (AP) — Cam Newton threw for 242 yards and four touchdowns, and the Panthers spoiled Aaron Rodgers’ return from a broken collarbone.

Damiere Byrd had two touchdown catches, and Christian McCaffrey had 136 yards from scrimmage, including a 7-yard touchdown reception as the Panthers (10- 4) won their fourth straight home game.

Greg Olsen had his most productive game since returning from a broken foot, catching nine passes for 116 yards and a TD.

Rodgers, making his first appearance since Oct. 15, threw for 290 yards with three touchdowns, but was intercepted three times as the Packers’ playoff hopes took a critical blow.

Green Bay (7-7) had a chance to send the game into overtime for a third straight week. But cornerback James Bradberry stripped wide receiver Geronimo Allison of the ball with 1:48 remaining.

Saints 31, Jets 19

NEW ORLEANS (AP) — Mark Ingram ran for two touchdowns and gained 151 yards from scrimmage, including a late 50-yard TD run, and the Saints overcame three turnovers.

Michael Thomas became the second NFL player with at least 90 receptions in his first two seasons. He caught nine passes for 93 yards, including a pivotal fourth-quarter touchdown for the Saints ( 10- 4), which retained its tenuous hold on first place in the NFC South heading into the final two weeks.

Ravens 27, Browns 10

CLEVELAND (AP) — Joe Flacco threw a touchdown pass, ran for a score and beat Cleveland again as the Ravens stayed on track for the AFC playoffs.

With victories at home over Indianapolis and Cincinnati in its last two games, the Ravens will return to the postseason after a two-year absence.

The Browns are two losses from becoming the NFL’s second 0-16 team.

Bills 24, Dolphins 16

ORCHARD PARK, N.Y. (AP) — LeSean McCoy scored twice and surpassed 10,000 career yards rushing, while helping the Bills stay in the thick of the AFC playoff hunt.

Tyrod Taylor also scored on a 9-yard touchdown run and Shareece Wright and Jordan Poyer intercepted Miami’s Jay Cutler on consecutive drives to start the second half. Buffalo never trailed. Rookie Tre’Davious White sealed the win by intercepting Cutler with 28 seconds remaining — and one play after Miami punter Matt Haack recovered an onside kick at Miami’s 37.

The loss all but mathematically eliminated the Dolphins (6-8) from playoff contention.

Redskins 20, Cardinals 15

LANDOVER, Md. (AP) — Anthony Lanier sacked Blaine Gabbert and forced a fumble that Preston Smith recovered and the Redskins held on to beat the Cardinals in a comedy of errors for each team.

Smith also intercepted Gabbert and Lanier batted down three passes and had two sacks as they gave the Redskins (6-8) a glimpse of their potential as significant pieces of the defense for years to come.