NORRISTOWN, Pa. — Bill Cosby’s retrial took a far more combative turn Tuesday than the first go-round, as his lawyers launched a scathing attack on his accuser and prosecutors put the first in a parade of women on the stand to portray the comedian as a sexual predator.

Heidi Thomas, who was a 24-year-old aspiring actress in 1984 when she met Cosby in Reno, Nevada, testified he knocked her out with a potent glass of wine and forced her to perform oral sex.

Prosecutors have lined up five accusers in all to make the case that the TV star, once revered as America’s Dad, made a habit of drugging and assaulting women well before he was charged with violating Andrea Constand at his Philadelphia area home in 2004.

Cosby’s lawyer urged jurors to ignore the other accusers – calling them irrelevant to this case – but saved most of his fire for Constand, branding her a “con artist” who tried to frame the comedian for the money.

Tom Mesereau, delivering his opening statement a day after prosecutors took their turn, said Constand “hit the jackpot” when Cosby paid her $3.4 million over a decade ago to settle her lawsuit against him.

“What did she want from Bill Cosby?” Mesereau said. “You already know the answer: money, money and lots more money.”

His attack on Constand was a striking departure from the more subdued tone that Cosby’s previous lawyer took at the first trial, which ended in a hung jury last spring.

It was also a likely glimpse of what’s to come when the former Temple University basketball administrator takes the stand to say Cosby made her woozy with pills and then penetrated her with his fingers.

Cosby, 80, is charged with three counts of aggravated indecent assault, each punishable by up to 10 years in prison.

As they began building their case against Cosby, prosecutors chose Thomas, now a Colorado music teacher, as their first substantive witness.

Thomas, who said her agent had arranged for Cosby to give her acting tips, told the jury that she took a sip of white wine that Cosby gave her as they rehearsed a scene in which she was portraying a drunken woman. Thomas said her next memory was waking up with Cosby forcing himself on her.

She said she remembered thinking she felt sick and wondering, “How did I get here?”

Thomas testified she blamed herself for what happened, thinking she must have said or done something that led Cosby to believe she would be open to his advances.