BOSTON — Blake Snell worked into the eighth inning and struck out nine, and the Tampa Bay Rays held off the Boston Red Sox 4-3 on Friday night for their seventh consecutive victory.

Xander Bogaerts returned to the Red Sox lineup after missing 15 games with an ankle injury. He went 3 for 4 in the Red Sox loss.

Wilson Ramos hit a two-run homer in the first inning for the Rays, who handed the Red Sox just their second loss in 10 home games and spoiled Xander Bogaerts’ return to Boston’s lineup. Rob Refsnyder and Daniel Robertson also homered for Tampa Bay.

Bogaerts had Boston’s first hit off Snell (4-1), a leadoff single in the fifth. He went 3 for 4 in his first action since missing 15 games with a broken bone in his left ankle.

Snell allowed two runs on five hits and one walk in 71/3 innings to win his fourth consecutive start. Alex Colome worked the ninth for his fifth save in seven opportunities, striking out pinch-hitter Andre Benitendi looking to end it.

Mookie Betts and J.D. Martinez hit RBI doubles for the Red Sox, who have lost 4 of 6.

Drew Pomeranz (0-1) lasted five innings in his second start of the season. Pomeranz, who missed the first 18 games with a forearm injury, allowed four runs, all on homers, struck out four and walked two.

Ramos’ two-out blast over the Green Monster scored C.J. Cron in the first. Refsnyder led off the third with another shot over the Monster, his first homer since October 2015.

Robertson led off the fourth with another homer to left.

Boston didn’t have a baserunner until Snell walked Betts to start the fourth.

Snell took a shutout into the sixth, when Christian Vazquez led off with a double off the wall in left and scored on Betts’ one-out double to center. Martinez drove in Betts with a two-out double down the line in right.

Betts doubled again in the eighth off Chaz Roe and scored on a single by Martinez.

Bogaerts missed more time than initially expected. Manager Alex Cora said he wasn’t going to rush the 25-year-old, an All-Star two years ago who was batting .368 with nine RBI at the time of his injury.

“I wasn’t going to push him just to have his name in the lineup,” Cora said. “I want him to feel comfortable and move around, and feel that his pace is there. It’s very important for him.”

Infielder/outfielder Brock Holt was put on the disabled list because of a strained left hamstring.

Bogarts was hurt April 8 while sliding into the Rays’ dugout to grab an errant ball. He went 2 for 3 with a home run and a double while playing six innings at shortstop Tuesday night in a rehab appearance for Triple-A Pawtucket.

Bogaerts played in Boston’s first nine games before getting hurt.

NOTES

The Rays activated third baseman Matt Duffy (strained right hamstring) from the 10-day disabled list and optioned right-hander Austin Pruitt to Triple-A Durham. … Right-hander Yonny Chirinos (0-1, 2.92 ERA), who will start Saturday for Tampa Bay, went 42/3 innings Sunday while allowing two runs on four hits in his first appearance as the Rays’ fourth starter. … Boston left-hander David Price (2-2) gets his third start in the first month of the season against his former club Saturday.

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