Kyle Manzardo celebrates hitting a solo home run in the first inning of the Guardians’ 3-2 win over the Twins on Thursday in Cleveland. Nick Cammett/Associated Press

CLEVELAND — Andrés Giménez singled home José Ramírez from second base in the 10th inning as the Cleveland Guardians clinched a playoff berth in dramatic, fitting fashion, beating the Minnesota Twins 3-2 on Thursday.

With Ramírez on second as the automatic runner, Minnesota reliever Caleb Thielbar (2-4) struck out Josh Naylor and the Twins walked Lane Thomas intentionally to face Giménez.

Cleveland’s second baseman then hit a 3-2 pitch into right to easily score Ramírez.

As the All-Star third baseman rounded third, Cleveland’s dugout emptied onto the field in celebration as the Guardians posted their MLB-leading 42nd comeback win and second straight in extra innings.

The Guardians are the second AL team to qualify for the postseason, following the New York Yankees, who locked up a spot Wednesday night.

Cleveland now has a chance to possibly end baseball’s longest active World Series drought, dating to 1948 when the team was known as the Indians.

The Twins threatened in the 10th, loading the bases with one out against Eli Morgan (3-0). But the right-hander got out of the jam by retiring Carlos Correa on a foul pop and Byron Buxton on a liner to right.

Cleveland’s bullpen, which has carried the team all season, combined for 5 2/3 hitless innings.

ORIOLES 5, GIANTS 3: Anthony Santander hit a game-winning home run – his 42nd of the season – and Baltimore edged closer to the postseason with a victory over San Francisco at Camden Yards.

Santander’s two-run shot off Ryan Walker (9-4) in the bottom of the ninth came after Casey Schmitt’s game-tying single off Seranthony Domínguez in the top half.

It landed just a few feet over the ground crew shed in right-center to end an afternoon that began with Baltimore having lost three in a row and eight of 10 to start five games behind New York in the AL East and 2.5 up on Kansas City for the top wild card place.

Gregory Soto (3-5) induced a quick double play in relief of Domínguez to keep the game tied.

BRAVES 15, REDS 3: Matt Olson hit two of Atlanta’s six home runs, Chris Sale coasted to his major league-leading 18th win and the Braves beat the Reds in Cincinnati.

The Braves became the first team in major league history to hit four three-run homers in a game, according to Elias.

Along with his career-best win total, Sale (18-3) also leads the majors in ERA (2.38) and strikeouts (225).

“I felt good. I was able to get through it,” said Sale, who is expecting to make two more starts and a chance to win 20 games. “This was a little bit of a grind but when the offense goes off like that, it takes a little bit off what I need to do.”

Sale pitched five innings, allowing two runs and five hits with two walks and six strikeouts. It was the 18th consecutive game in which he allowed two runs or fewer.

MARINERS 3, YANKEES 2: Logan Gilbert allowed two runs pitching into the sixth inning and reached the 200-strikeout mark for the season, J.P. Crawford had a key two-out RBI single as part of Seattle’s three-run first inning, and the Mariners won at home.

Seattle salvaged the final game of the series and stayed on the fringes of the playoff race, pulling within two games of Minnesota and Detroit for the final wild-card spot in the American League ahead of a six-game road trip to Texas and Houston.

A day after clinching a postseason berth, the Yankees had their lead in the AL East trimmed to four games after Baltimore’s victory. They also received a major scare from star outfielder Juan Soto in the seventh inning.

METS 10, PHILLIES 6: Mark Vientos, Pete Alonso, Brandon Nimmo and Francisco Alvarez homered off Taijuan Walker, and New York scored 10 runs in three straight games for the first time in their 63-year history with a win over visiting Philadelphia.

Philadelphia, which leads the NL East by six games over second-place New York, failed in its second attempt to clinch after losing Wednesday at Milwaukee. The Phillies would clinch a playoff berth with one win over the Mets during the four-game series and would clinch their first division title since 2011 with two victories over the Mets this week.

New York won its fourth straight game and for the 16th time in its last 20, maintaining a two-game lead over Atlanta for the NL’s final wild-card position.

BLUE JAYS 4, RANGERS 0: Kevin Gausman pitched five no-hit innings before exiting with lower back tightness, Vladimir Guerrero Jr. hit two solo homers after that and Toronto in Arlington, Texas to avoid a series sweep.

NOTES

BLUE JAYS: Shortstop Bo Bichette will end his season on the injured list because of a broken right middle finger after returning for only one game after he had been out more than eight weeks with a calf injury.

The two-time All-Star was put on the 10-day IL, two days after he had been activated and played his first game since July 19.

Bichette went 2 for 5 with an RBI on Tuesday night against Texas. He was supposed to be back in the Blue Jays lineup Wednesday, but broke the finger on his right (throwing) hand when taking groundballs before the game, and X-rays revealed the broken bone.