The Maine Turnpike was closed between Scarborough and Saco for several hours Friday night after four vehicles collided in a chain reaction, police said.

Jason McAvoy, a 59-year-old Old Orchard Beach resident, was driving a U-Haul south on the turnpike when he collided with a tanker truck driven by Kenneth Openshaw, of Massachusetts, Maine State Police said in a written statement Friday night.

From there, the tanker truck shot forward and struck a Subaru driven by Thomas Gillis, 32, another Old Orchard Beach Resident, the department said. Propelled by the tanker, Gillis’ car then rear-ended a Dodge Ram operated by Searsmont resident Zachary Taylor, 31.

The crash shut down all three lanes of southbound traffic between exits 42 and 36 for several hours. Maine State Police began receiving reports of the crash shortly after 6 p.m., the department said.

Police arrived to find McAvoy trapped inside the U-Haul. He was transported to Maine Medical Center. The other drivers were treated on the scene.

Investigators believe driver fatigue and inattention were the main contributing factors of the crash.

One lane had reopened by 9:10 p.m., with the road fully reopened a few minutes later, the department said.

Multiple vehicles were involved in at least one crash near mile marker 39, a dispatcher said shortly before 7 p.m. The road was reported closed between exits 36 and 42 on the Maine Turnpike Authority’s website just before 6:30 p.m.

The Scarborough Police Department did not immediately return a request for more information Friday evening. It was not clear how many people were involved or whether anyone was injured.

Google Maps indicated that southbound traffic was backed up heavily at 7 p.m.

Aaron Turcotte, Maine State Police spokesperson, said the road was closed while “State Police and first responders investigate a serious crash” in a written statement around 7 p.m. He said the department would release more details later Friday night.

This story will be updated as more information is made available.