TORONTO – A tough start to September is costing the Boston Red Sox a chance to catch the first-place New York Yankees.

Now, as they head to Tampa Bay for a four-game set, the Red Sox must make sure they continue to keep the Rays at bay in the wild-card race.

Ricky Romero won for the seventh time in nine starts, J.P. Arencibia hit a three-run homer and the Toronto Blue Jays beat the Red Sox 7-4 on Thursday night, Boston’s seventh defeat in 10 games.

The Red Sox dropped to 2-6 in September and failed to gain ground on the Yankees, who lost 5-4 in 10 innings to Baltimore earlier in the day. The Red Sox are 21/2 games behind New York with 19 left to play.

“I don’t really get too concerned about what they’re doing,” Manager Terry Francona said of the Yankees. “We try to spend our energy worrying about what we do.”

Still, catcher Jason Varitek called it “an opportunity lost,” while struggling second baseman Dustin Pedroia said the Sox need to improve.

“We’re trying to win the division,” Pedroia said. “Playing like this, it’s not going to happen, so we’ve got to play better.”

Despite the slow start to September, designated hitter David Ortiz hasn’t lost confidence.

“That’s part of the game, that’s part of the long season,” Ortiz said. “We’re good at dealing with it. I’m pretty sure everybody is going to pull themselves together and fight for the rest of the season.”

Edwin Encarnacion and Eric Thames added solo shots as Toronto won back-to-back games for the first time since Aug. 31 and Sept. 1 at Baltimore.

Rookie David Cooper went 3 for 4 and had two RBI as Toronto evened its record at 72-72.

Romero (14-10) came in 2-6 with an 8.08 ERA in 11 career starts against the Red Sox, including an 0-3 record and 10.62 ERA in five home starts. But he turned his luck around, allowing three runs and five hits in 62/3 innings. He walked three and struck out seven.

“It feels good to beat those guys,” Romero said. “They’ve been on me for the past few years. I finally had a good outing against them and it’s definitely satisfying.”

Romero has lost once since July 21, dropping a 6-4 decision at Yankee Stadium on Sept. 3.

“The one thing Ricky does, he doesn’t leave anything on the field,” Blue Jays Manager John Farrell said. “He gives his all every single time he walks to the mound, and when you go up against opponents like tonight, you have to be at your best.”

Casey Janssen worked 11/3 innings and Frank Francisco pitched around Jason Varitek’s homer in the ninth to end it.

A two-out error by Kelly Johnson and a base hit by Marco Scutaro brought Pedroia to the plate as the tying run, but Francisco struck him out to end it.

Pedroia finished 0 for 5 and struck out three times. He went 1 for 20 in the series.

“He’s probably trying a little too hard,” Francona said. “He feels so much responsibility when we’re not clicking to do it by himself. That’s one characteristic we love about him.”

Toronto opened the scoring with four in the second against left-hander Andrew Miller (6-3). Johnson reached on an infield single, advanced to third on Brett Lawrie’s base hit to right and scored on a single by David Cooper. Arencibia followed with a drive into the third deck in left, his 22nd of the season and second in as many days.

“That one inning just really snowballed and I wasn’t able to stop it quick enough,” Miller said.