BOSTON — The Boston Celtics played without new addition Al Horford for the first time this season on Wednesday night.

Thanks to Isaiah Thomas and Amir Johnson, they didn’t miss a beat.

Thomas had 23 points and 10 assists, Johnson finished 23 points – including a career-high four 3-pointers – and the Boston Celtics handed the Chicago Bulls their first loss of the season, 107-100.

Boston avenged its lone setback of the season despite being without Horford, who was placed in the concussion protocol Tuesday after exhibiting concussive symptoms during practice.

Johnson was active from all over the court, scoring 16 points in the third quarter. The Bulls managed just 18 points in the quarter, their lowest scoring quarter of the season.

“I just made the first one and my confidence got a little higher,” Johnson said of his 3-point performance. “When I knocked down the fourth one, I don’t even think I even saw the basket.”

The Bulls cut into what had been a 16-point Boston lead in the fourth quarter and tied it at 100 on two free throws by Nikola Mirotic. But Boston regained the lead 101-100, then went up five on a driving layup by Thomas and a basket by Marcus Smart.

Jimmy Butler led Chicago with 23 points and nine rebounds.

Before Wednesday Johnson had never made more than two 3-pointers in a game and had never attempted more than four. He entered the night 0 for 1 on the season.

Boston led by as many as 14 points in the first half, but took only a two-point lead into halftime.

After a slow start, Jae Crowder scored eight straight points during a 21-4 Boston run. The Bulls stayed in it via a few mini spurts, including an 8-0 run by Butler.

But Crowder will join Horford on the injured list after he left in the second quarter with a left ankle sprain. Coach Brad Stevens said he doesn’t expect Crowder back “any time soon.”

“It’s a great opportunity for everybody else,” Stevens said. “We’re early in the season, so everybody gets a chance to step up and make plays and compete. And we’ll see. We’ll try to figure it out.”

Stevens said Horford would also sit out Boston’s game Thursday against the Cavaliers. A teammate inadvertently swiped Horford in the face with the ball during practice on Monday, but Horford didn’t show any initial symptoms. But he experienced some nausea in practice on Tuesday and was pulled.