IOWA CITY, Iowa — Nate Stanley threw for 226 yards and five touchdowns Saturday, and Iowa throttled third-ranked Ohio State 55-24, dealing what’s likely to be a fatal blow to the Buckeyes’ playoff hopes.

Josh Jackson added three interceptions for the Hawkeyes (6-3, 3-3 Big Ten) against the Buckeyes (7-2, 5-1). Iowa beat its fourth top-5 opponent in its last five tries at home.

(2) GEORGIA 24, SOUTH CAROLINA 10: Jake Fromm threw two touchdown passes as Georgia (9-0, 6-0 Southeastern) defeated South Carolina (6-3, 4-3) at Athens, Georgia.

(4) WISCONSIN 45, INDIANA 17: Jonathan Taylor rushed for 183 yards and one touchdown, and Alec Ingold had three scores to help Wisconsin (9-0, 6-0 Big Ten) pull away from Indiana (3-6, 0-6) at Bloomington, Indiana.

(5) NOTRE DAME 48, WAKE FOREST 37: Brandon Wimbush passed for a career-high 280 yards and ran for two touchdowns as Notre Dame (8-1) won its seventh straight, beating Wake Forest (5-3) at South Bend, Indiana.

(6) CLEMSON 38, (20) NORTH CAROLINA STATE 31: Tavien Feaster ran for an 89-yard touchdown to end the third quarter and K’Von Wallace picked off Ryan Finley on the game’s final play to help Clemson (8-1, 6-1 Atlantic Coast) hold off North Carolina State (6-3, 4-1) at Raleigh, North Carolina.

(24) MICHIGAN STATE 27, (7) PENN STATE 24: Matt Coghlin kicked a 34-yard field goal as time expired to give Michigan State (7-2, 5-1 Big Ten) a victory over Penn State (7-2, 4-2) in a game that was delayed nearly 31/2 hours by severe weather in the second quarter at East Lansing, Michigan.

(8) OKLAHOMA 62, (11) OKLAHOMA STATE 52: Baker Mayfield passed for a school-record 598 yards and Oklahoma (8-1, 5-1 Big 12) outlasted Oklahoma State (7-2, 4-2) at Stillwater, Oklahoma.

WEST VIRGINIA 20, (14) IOWA STATE 16: Will Grier threw two scoring passes and Justin Crawford rushed for 102 yards as West Virginia (6-3, 4-2 Big 12) beat Iowa State (6-3, 4-2) at Morgantown, West Virginia.

(16) AUBURN 42, TEXAS A&M 27: Jarrett Stidham threw for 268 yards and three touchdowns as Auburn (7-2, 5-1 Southwestern) pulled away in the second half from Texas A&M (5-4, 3-3) at College Station, Texas.

(25) WASHINGTON STATE 24, (18) STANFORD 21: Luke Falk threw for 337 yards and three touchdowns, and Washington State (8-2, 5-2 Pac-12) beat Stanford (6-3, 5-2) at Pullman, Washington, keeping alive its hopes for a Pac-12 North title.

(21) MISSISSIPPI STATE 34, MASSACHUSETTS 23: Nick Fitzgerald ran for 135 yards and two touchdowns to lead Mississippi State (7-2) over UMass (2-7) at Starkville, Mississippi.

JAMES MADISON 39, RHODE ISLAND 3: Bryan Schor threw four touchdown passes and James Madison (9-0, 6-0 Colonial Athletic) overcame a slow start to defeat Rhode Island (2-7, 1-5) at Kingston, Rhode island.

DARTMOUTH 10, CORNELL 0: Jack Heneghan’s first-quarter touchdown pass helped Dartmouth (6-2, 3-2 Ivy) outlast Cornell (3-5, 3-2) at Hanover, New Hampshire.

HARVARD 21, COLUMBIA 14: Joseph Viviano III threw for two touchdowns and ran for a third, Joey Goodman broke up a fourth-down pass in the end zone with 31 seconds left and Harvard (5-3, 3-2 Ivy) defeated Columbia (6-2, 3-2) at New York.

HOLY CROSS 42, FORDHAM 20: Peter Pujals completed a key pass to Blaise Bell on fourth-and-9 late in the first half and Holy Cross (4-6, 3-2 Patriot) scored on the next play to begin a stretch of five unanswered touchdowns to roll past Fordham (3-7, 2-3) at New York.

NEW HAMPSHIRE 35, WILLIAM & MARY 16: Trevor Knight passed for 406 yards and a career-high four touchdowns as New Hampshire (6-3, 4-2 Colonial Athletic) beat William & Mary (2-7, 0-6) at Williamsburg, Virginia.

SOUTH FLORIDA 37, CONNECTICUT 20: Quinton Flowers threw for 385 yards and three touchdowns as South Florida (8-1, 5-1 American Athletic) pulled away from UConn (3-6, 2-4) at East Hartford, Connecticut.