NEW YORK — UConn is back in a familiar place – the No. 1 overall seed in the women’s basketball NCAA tournament.

Joining the Huskies as top seeds are Notre Dame, Louisville and Mississippi State.

The Huskies enter as the lone unbeaten team and will be vying for their 12th national championship. It’s the ninth time that UConn has entered the NCAAs undefeated, including last year when the Huskies went in as the overwhelming favorite before their 111-game winning streak ended with a loss to Mississippi State in the Final Four.

This year’s Final Four is in Columbus, Ohio, and will take place March 30. The national championship game is on Sunday, April 1.

Defending national champion South Carolina and A’ja Wilson await as a possible Elite Eight matchup for UConn in the Albany Regional. The Gamecocks are the No. 2 seed.

“What can you do? You have to beat some pretty good teams. Is it an impossible feat? Obviously not,” South Carolina Coach Dawn Staley said. “We saw that last year. If we’re in the position where we have to play them, we’re going to play them.

The Gamecocks lost by 25 at home against UConn on Feb. 1.

Florida State and Georgia are the other top seeds in the Huskies’ part of the bracket.

UConn, which has been a No. 1 seed every year since 2007, opens up against 16th-seed Saint Francis (Pennsylvania) on Saturday morning. All four top seeds play the opening two rounds at home.

Like the Huskies, the Irish are a No. 1 seed again. Notre Dame has been a top seed the last seven years.

This might be one of Coach Muffet McGraw’s finest accomplishments because Notre Dame lost four pivotal players to injury but only three games on the season. Two of those losses came to Louisville.

The Irish are in the Spokane Regional and open against Cal State Northridge on Friday. If Notre Dame advances, it would head out west to potentially face No. 2 seed Oregon.