MIAMI — Hanley Ramirez hit a two-run double with two out in the 13th inning, and another night of stingy pitching helped the Boston Red Sox extend their winning streak to five games by beating the Miami Marlins 4-2 Tuesday.

Mookie Betts singled with one out in the 13th off Tayron Guerrero (0-1) and advanced on a groundout. Following an intentional walk to Andrew Benintendi, Ramirez lined his third extra-base hit of the season.

Heath Hembree (1-0) allowed one hit in two innings to help the Red Sox (5-1) to their best start since 2006.

Red Sox ace Chris Sale allowed only one run, and it was tainted, but he needed 93 pitches to get through five innings. Boston starters have allowed less than two runs in each of their six games, the longest such streak in the majors to begin a season, according to Elias.

After two starts, Sale has an ERA of 0.82 but no decisions. The Red Sox have a team ERA of 2.21.

After Red Sox closer Craig Kimbrel pitched around a single, stolen base and walk in the 10th, Boston took a 2-1 lead in the 11th. Matt Barnes then blew a save when Cameron Maybin hit a two-out RBI double, but shortstop Xander Bogaerts threw out Justin Bour trying to score from first on the play.

Marlins center fielder Lewis Brinson robbed Betts of a pinch-hit homer with a leaping catch above the wall to start the 11th. Eduardo Nunez followed with a double off Odrisamer Despaigne, and scored on Benintendi’s single.

Miami’s Jose Urena overcame a 26-pitch first inning to go seven innings. He allowed one run and tied a career high with seven strikeouts.

The Marlins have gone overtime in three games and played 13 extra innings.

The Red Sox wrapped up 50 consecutive days in Florida, starting with spring training, and will play their Fenway Park opener Thursday afternoon against Tampa Bay.

It was a road game for the Red Sox, but it didn’t feel like it for Manager Alex Cora.

A local hero in in South Florida for his three years at the University of Miami, where he led the Hurricanes to the College World Series in all three years from 1994-96, Cora had 25 friends and family members in the stands at Marlins Park.

The Sox and Marlins played Tuesday night and the game did not end before deadline.

“Those three years that I spent here, I had a blast,” Cora said. “I grew up a lot, not only as a player but as a person. This is my second home.

“I’m a Cane for life. I love the Hurricanes and I love this city so it’s fun to be here.”

Cora grew up in Puerto Rico but said he watched Miami on ESPN and became a huge fan. He chose not to sign with the Minnesota Twins, who drafted him in the 12th round in 1993, and instead his stock jumped quite a bit after his three strong years for the ‘Canes.

After three strong years at Miami, where he had at least 60 hits in each season while well-regarded for his play at shortstop, Cora was drafted in the third round by the Los Angeles Dodgers and went on to play 14 MLB seasons.

“So out of all the guys at Miami, Warren Sapp was there, Ray Lewis was here, the Rock, Dwayne Johnson,” Cora said.

Cora was inducted in the University of Miami Hall of Fame in 2006.

“Out of all the guys, Warren Sapp, I see him, he’s one of my favorites,” Cora said. “Ray Lewis. And then from the other good teams in 2001, I was able to meet him, Ed Reed, he’s my favorite player.”

Eduardo Rodriguez and Drew Pomeranz are almost ready for minor league rehab assignments.

Pomeranz, coming back from a flexor tendon strain, threw five innings at the Red Sox’ minor league complex Monday.

Rodriguez, making his way back from knee surgery, was scheduled to throw six innings there Tuesday.