BOSTON — Rookie Jayson Tatum scored 21 points and hit a pair of free throws in the closing seconds, and the Boston Celtics rallied from a 22-point deficit to beat the Philadelphia 76ers 108-103 on Thursday night and take a 2-0 lead in the Eastern Conference semifinals.

Terry Rozier added 20 points, nine assists and seven rebounds. Marcus Smart finished with 19 points and five rebounds as the Celtics improved to 6-0 at TD Garden this postseason. They have never blown a 2-0 lead.

Game 3 is Saturday in Philadelphia.

J.J. Redick had 23 points for the 76ers, making five 3-pointers. Robert Covington added 22 points and nine rebounds. Joel Embiid finished with 20 points, 14 rebounds and five assists.

Philadelphia recovered after squandering its big lead to nudge back in front 93-88 midway through the fourth quarter.

But an 11-4 run put Boston back in the lead 99-95 with less than four minutes to play.

It was 101-97 when a missed Philadelphia jumper led to a two-on-one fast break and alley-oop dunk from Rozier to Tatum with 2:23 left.

A layup by Dario Saric cut it to 104-101. But Al Horford was able to drive past Embiid for a layup with 8.3 seconds left.

Saric scored out of a timeout to make it 106-103. The Sixers quickly fouled Tatum, who calmly hit a pair of free throws.

Following an anemic offensive effort in Game 1, the Sixers looked rejuvenated early in Game 2, using a 14-2 run to begin the second quarter on their way to building a 48-26 lead.

It didn’t last.

The Celtics responded by ending the half on a 25-8 run. It included three straight 3-pointers and a tip-dunk by Jaylen Brown, who returned to action after sitting out the series opener with a strained right hamstring. He came off the bench and played 25 minutes, scoring 13 points and grabbing four rebounds.

The Sixers’ lead was completely erased midway through the third quarter, when Aron Baynes got a 3-pointer to bounce in and put Boston in front for the first time.

The lead grew to 76-68 on a baseline dunk by Tatum that capped a 50-20 Celtics run.

Brown entered the game for the first time at the 7:14 mark of first quarter. It took less than a minute to make an impact. He missed his first shot attempt before chasing down a loose ball and sprinting ahead for a one-handed dunk .

Prior to Thursday, Brown had started every game he’d appeared in this season. It was his first time off the bench since Game 5 of last season’s Eastern Conference finals.

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