NEW YORK — Jonathan Loaisiga pitched three-hit ball over five impressive innings Friday night to win his major league debut, and the New York Yankees beat the Tampa Bay Rays, 5-0.

Didi Gregorius homered off ex-Yankee Nathan Eovaldi, and Gary Sanchez broke out of a long slump with a three-run double in the eighth. Giancarlo Stanton had a sacrifice fly for New York, which improved the best record in the majors to 45-20.

Jonathan Holder, David Robertson, Dellin Betances and Adam Warren each worked an inning to finish the four-hitter.

Loaisiga (1-0) was called up from Double-A Trenton to fill in for injured starter Masahiro Tanaka. The 23-year-old right-hander, who walked only four batters in 45 minor league innings, struggled a little with his command, issuing four walks and striking out six.

TWINS 6, INDIANS 3: Corey Kluber had a rare rocky performance, lasting just five innings and losing for the first time in seven starts as Kyle Gibson outpitched the Cy Young winner and Brian Dozier hit a two-run homer to lead Minnesota at Cleveland.

Kluber (10-3) allowed a homer on his fourth pitch of the game to Eddie Rosario and was pulled after throwing just 65 pitches by Manager Terry Francona.

NATIONAL LEAGUE

PIRATES 3, REDS 2: Chad Kuhl pitched six solid innings to win for the first time in more than a month for Pittsburgh at home.

Kuhl (5-4) gave up two runs, one earned, and six hits, striking out six and walking three. It was his first win since May 6 at Milwaukee, a span of seven starts, though Kuhl allowed no more than three runs in any of his previous four outings.

PADRES 9, BRAVES 3: Hunter Renfroe hit a go-ahead, two-run single in a five-run seventh inning, Freddy Galvis had a three-run homer and went 5 for 5, and San Diego won at Atlanta.

Freddie Freeman’s 15th homer gave Atlanta a 3-2 lead in the fifth. Jose Pirela hit a two-run homer for San Diego in the first.

INTERLEAGUE

BLUE JAYS 6, NATIONALS 5: Yangervis Solarte homered from both sides of the plate, Devon Travis also connected and Toronto earned its fifth straight home victory.

Washington has lost 5 of 7 on the road.

MARLINS 2, ORIOLES 0: Jose Urena pitched eight innings of three-hit ball, Lewis Brinson tripled twice and Miami won at Baltimore to stretch the Orioles’ losing streak to a season-high eight games.

The Marlins scratched out a couple of runs against Kevin Gausman (3-6) for their fourth win in five games.

NOTES

ANGELS: Los Angeles lost four more players to the disabled list, putting the club’s total at a franchise-record 15 players on the DL at one time.

Infielder Zack Cozart went on the DL with a partially dislocated right shoulder; right-hander Jim Johnson has a lower back strain; right-hander Garrett Richards is nursing a strained left hamstring; and right-hander Nick Tropeano has inflammation in his pitching shoulder.

ORIOLES: Reliever Richard Bleier is likely lost for the year with a shoulder injury, yet another setback for the team with the worst record in the major leagues.

Bleier (3-0, 1.93 ERA) was the most effective pitcher in a bullpen that only recently got back the injured Zach Britton and Darren O’Day.

INDIANS: Starting first baseman Yonder Alonso will miss at least three games after being placed on the family-medical-emergency list.

Cleveland also activated center fielder Tyler Naquin from the disabled list. He had been sidelined with a hamstring injury since May 11.

PIRATES: Infielder Jung Ho Kang was reinstated from the restricted list and optioned to Triple-A Indianapolis after missing last season and the first part of this year because of visa issues.

Kang, 31, was unable to secure a work visa to travel from his native South Korea to the United States after he was arrested for DUI for a third time in December 2016 in Seoul. He received an eight-month suspended sentence.