ALBANY, N.Y. — Katie Lou Samuelson put UConn on her injured back and shot the Huskies into a record 12th straight Final Four.

Samuelson scored 29 points and second-seeded UConn held off No. 1 Louisville 80-73 on Sunday in the Albany Regional final.

“She made some shots today that only really special players make at this particular time,” UConn Coach Geno Auriemma said. “This is when players separate themselves in these games.”

The Huskies (35-2) have won six national championships and had a 111-game winning streak during their remarkable Final Four run. They will try to reach the title game for the first time in three years after losing on last-second shots in the past two national semifinals.

“I don’t think it’s supposed to happen,” Auriemma said of the incredible run. “Not in today’s world the way things change and teams keep getting better and better. It’s not normal.

It’s something that’s hard to describe because even if you’re writing a book and making it up, people would say it doesn’t happen in real life. It has happened in real life, I’m still boggled, my mind doesn’t get how it can happen this many years in a row with a different cast of characters that change so often. No it’s not normal, it’s not normal.”

Samuelson hit seven of the team’s 14 3-pointers, including many big shots in the fourth quarter.

“I wanted to keep my career going,” she said. “I had to step up. They were really making it hard for us, so I had to do what I could.”

UConn needed every one of them as the team nearly blew an 11-point lead in the final 1:47 of the game.

Louisville scored 10 of 11 points to cut its deficit to 75-73 with 26.6 seconds left. Samuelson then hit two free throws to make it a two-possession game.

Asia Durr was fouled a few seconds later, but the Cardinals’ senior leader missed both free throws. Napheesa Collier was fouled after the Cardinals’ missed a chance on an offensive rebound. She sank both free throws on the other end to make it 79-73.

As the buzzer sounded, the Huskies mobbed Samuelson at the foul line, celebrating another trip to the Final Four.

“It’s amazing just to be part of this program, just to wear this name on our chest every day,” Samuelson said. “You know you’re part of something special. And they’ve created something amazing here. And for us, we just want to be part of that and keep it going as long as we can.”

Louisville (32-4) was looking to become only the second team to beat UConn twice in a season in the last decade, joining fellow ACC school Notre Dame, which did it in 2012 and 2013. The Huskies could face the Irish in the Final Four in Tampa if Notre Dame beats Stanford in the Chicago Regional final on Monday night.

UConn was not a No. 1 seed for the first time since 2006. While much was made of that leading up to this game, the only real differences, as Auriemma put it, was that his team would wear the road blues and would be sitting on a different bench. The Huskies band also played the national anthem pregame. It certainly wasn’t a road game, though, with a very pro UConn crowd of 9,204 at site a 2-hour drive from Connecticut.

Samuelson has been dealing with a back injury since getting hurt against Houston in the final home game of the regular season. She missed the entire American Athletic Conference tournament. She struggled in the Sweet 16 victory over UCLA, scoring just six points and not hitting a basket until the fourth quarter.

She was much better against Louisville despite being saddled with foul trouble.

Her fifth 3-pointer of the game late in the third quarter gave UConn a 10-point lead. She soon after picked up her fourth foul, and Louisville was able to cut its deficit to 57-53 heading into the final quarter.

The Cardinals hung around and were only down 66-62 when Samuelson hit another 3-pointer. With 3:02 left, Samuelson was fouled while making a 3-pointer. She missed the free throw, but UConn had a 72-63 lead.

“It was a great basketball game. There was a lot of big plays made by both teams, unfortunately for us they made a few more,” Louisville Coach Jeff Walz said. “If you didn’t sit back and watch this game and appreciate how it was being played, then it’s a shame.”

Durr saw her brilliant career come to an end as she scored 18 of her 21 points in the second half to lead the Cardinals.

Samuelson got UConn going early. She hit a 3-pointer from the wing in the first quarter as UConn scored the first seven points of the game.

Louisville bounced back with a 9-0 run to go up 16-12. The Huskies scored the final 10 points of the quarter to lead 22-16. Durr missed all eight of her shots in the quarter, but did have five rebounds and three assists.

The lead grew to 10 before Louisville made a run to get within four. The Huskies were up 41-34 at the half, as Megan Walker scored 12 of her 13 points and hit four of UConn’s nine 3-pointers in the opening 20 minutes. UConn only made eight 3s in the loss to Louisville in January.