Houston second baseman Jose Altuve, San Francisco Giants pitcher Carlos Rodón, St. Louis Cardinals third baseman Nolan Arenado and Miami Marlins second baseman Jazz Chisholm Jr won’t be playing in Tuesday’s All-Star Game.

Altuve, an eight-time All-Star who was selected as a starter in fan voting, was struck on the left knee leading off Thursday’s game against the Los Angeles Angels. He was kept out of the lineup Friday night.

MLB announced Saturday that Altuve is being replaced in the starting lineup by Cleveland’s Andrés Giménez, who is making his first appearance. Toronto’s Santiago Espinal will replace Altuve on the AL roster.

Dodgers pitcher Tyler Anderson is taking the place of Rodon on the NL roster, the team said in a news release. It wasn’t immediately clear why Rodon isn’t playing in the All-Star Game. Anderson is 10-1 with a 2.96 ERA in 17 games, with 81 strikeouts.

Atlanta third baseman Austin Riley, who has 100 hits and a .913 OPS this season, will replace Arenado on the NL team.

Arenado, a seven-time All-Star, said Saturday that he’s had lower back soreness for three to four weeks, that MRIs found nothing, and that he’ll take the All-Star break to rest.

“It’s been a problem lately It didn’t really make sense for me to go do that,” said Arenado, who lives less than an hour from Los Angeles. “Probably made more sense for me to go home, relax and just chill. Go home. Get treatment. Get some work done. I’ve got some trainers. I’ve got a physical therapist back home, ready to go.”

Altuve said of his knee on Saturday that he was “waiting to see how it responded today and I think we all agree that we’re making the best decision.” He also said “I don’t think we’re going to go” when asked if he was going to go to L.A., adding “we’re going to do some treatment and get ready for the second half.”

San Diego’s Jake Cronenworth will take the place of Chisholm, who has been on the injured list since June 29 because of a right lower back strain.

RAYS: Tampa Bay center fielder Kevin Kiermaier said after being moved to the 60-day injured list that he could miss the rest of the regular season because of a left hip injury.

Kiermaier, a Gold Glove-caliber outfielder, hasn’t played since July 9. He is hitting .228 with seven homers, 22 RBI with six stolen bases in 63 games this year.

“Yeah, it is (tough to grasp),” Kiermaier said. “It hasn’t really hit me just yet. … For right now I’m kind of in that limbo, in-between period but I think we will all know more here shortly.”

The earliest he could return from the IL is September. Kiermaier is scheduled to see a specialist in Nashville after the All-Star break. A surgical procedure hasn’t been ruled out.

SATURDAY’S GAMES

MARINERS 3, RANGERS 2: J.P. Crawford hit an RBI single in the 10th inning and visiting Seattle stretched its winning streak to 13 games.

Carlos Santana homered as the Mariners (50-42) moved closer to the club-record 15-game winning streak set in their last playoff season in 2001.

ORIOLES 6, RAYS 4: Ryan Mountcastle hit a two-run single in the 11th inning, and Baltimore won in St. Petersburg, Florida, a day after its 10-game winning streak ended.

CARDINALS 11, REDS 3: Paul Goldschmidt hit his 300th career homer and drove in three runs, Albert Pujols reached another milestone and St. Louis won at home.

Goldschmidt’s two-run homer in the second inning was his 20th this season and first since June 27.

Goldschmidt, 34, became the 153rd player to reach 300 homers.

Pujols, 42, scored twice. He tied Hall of Famer Lou Gehrig for 12th place with 1,889 runs scored.

ASTROS 5, ATHLETICS 0: Justin Verlander struck out 10 in six sharp innings to post his MLB-leading 12th win and Houston beat visiting Oakland.

Martín Maldonado hit a second-inning grand slam as the AL West-leading Astros bounced back after a 5-1 loss in the series opener Friday night.

Verlander (12-3) allowed six hits without a walk and lowered his ERA to 1.89, which ranks third in the majors.

BLUE JAYS 6, ROYALS 5: Teoscar Hernández singled home the winning run in the bottom of the 10th inning as Toronto edged Kansas City.

Royals designated hitter Vinnie Pasquantino hit a tiebreaking home run in the top of the 10th inning to put Kansas City up 5-3, but Toronto rallied for three runs in the bottom half against former Blue Jays reliever Joel Payamps (2-3).

METS 2, CUBS 1: Pete Alonso hit a sacrifice fly in the 11th inning after Adam Ottavino worked out of a tricky jam, helping New York win at Chicago in the opener of a day-night doubleheader.

The Cubs lost their eighth in a row.

ROCKIES 2, PIRATES 0: Kris Bryant had three hits and an RBI, Charlie Blackmon extended his hitting streak to seven games with an RBI single, and Jose Urena pitched six scoreless innings in Colorado’s win at Denver.

TWINS 6, WHITE SOX 3: Jorge Polanco hit a three-run homer, one of three home runs for Minnesota against Lance Lynn, in a five-run third inning and Minnesota held on for a win at home.

First-time All-Star Luis Arraez led off the bottom of the first with a homer and Carlos Correa added a two-run shot in the third for the Twins, who had lost six of eight.

GUARDIANS 10, TIGERS 0: José Ramírez tuned up for the All-Star Home Run Derby by homering in his first two at-bats and driving in five runs – on his bobblehead giveaway day – to power Cleveland to a rout at home.

PHILLIES 10, MARLINS 0: Kyle Schwarber hit his NL-leading 29th homer, J.T. Realmuto had a homer and a double, and visiting Philadelphia spoiled the major league debut of touted Miami pitcher Max Meyer.

Didi Gregorius and Rhys Hoskins also went deep for the Phillies, who had not scored more than three runs in their previous seven games. Gregorius finished with four RBI.

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