BOSTON — The last time the Toronto Blue Jays faced Clay Buchholz of the Boston Red Sox, Edwin Encarnacion was left out of the starting lineup because of his career numbers against him.

This time Encarnacion was too hot to sit.

“I don’t think you can get any hotter than this,” Blue Jays Manager John Gibbons said Wednesday night after Encarnacion led Toronto to a 6-4 victory by hitting two homers off Buchholz – his second straight multi-homer game. “He erased all that, though.”

Xander Bogaerts had three hits, including two doubles, as Boston lost its sixth consecutive game. It’s the team’s longest losing streak since dropping the final eight games of the 2012 season, ending the Bobby Valentine era after one year.

Entering the game with one hit in 21 at-bats against Buchholz (2-4), Encarnacion hit a solo homer in the second inning and a two-run shot in the third. Encarnacion, who homered twice in Toronto’s 7-4 victory Tuesday, has seven homers in his last six games.

He is the first Toronto player to have four multi-homer games in a month, and the first major leaguer to do so since Troy Tulowitzki in September 2010.

“It’s crazy how this game is,” Encarnacion said. “In April I only had two homers; now I have (11) this month and two in one day. That shows you how crazy this is.”

Drew Hutchison (3-3) allowed one run in 51/3 innings for Toronto, which has won seven of its last nine games. Casey Janssen pitched the ninth for his fifth save.

Buchholz allowed four earned runs in 42/3 innings, striking out two, walking two and giving up nine hits, including two homers to a batter he had dominated.

“He’s a dangerous hitter with tremendous power,” Red Sox Manager John Farrell said. “You make mistakes, he makes you pay. This is a quick-strike offense.”

The Blue Jays made it 4-0 after three innings thanks to Encarnacion’s two homers into the seats above the Green Monster. Shane Victorino homered for Boston – his first since a grand slam in Game 6 of the AL Championship Series against the Detroit Tigers – to make it 4-1.

Dioner Navarro’s RBI single in the fifth made it 5-1 and chased Buchholz. The Blue Jays added another run in the seventh on Anthony Gose’s single.

The Red Sox scored three in the eighth to make it a two-run game thanks partly to back-to-back RBI doubles by Mike Carp and Bogaerts.

Brock Holt singled to score Bogaerts before Brett Cecil struck out Grady Sizemore and then Steve Delabar, on his first pitch, retired Dustin Pedroia on a groundout.

NOTES: A.J. Pierzynski, who was hitless in 11 straight at-bats, raised his hands to the heavens after singling in the sixth inning. He had just two hits in his previous 27 at-bats. Pierzynski wound up with three hits, including one off the first baseman’s mitt in the ninth inning. … Encarnacion has 15 multi-homer games in his career, four this season. … Buchholz had allowed three earned runs or fewer in three of his previous four starts.