LOUISVILLE, Ky. — The first big upset of the NCAA Tournament goes to the scrappy UAB Blazers.

William Lee scored the last four points for 14th-seeded UAB, and the Blazers upset third-seeded Iowa State 60-59 on Thursday in their opening game of the NCAA Tournament.

The Blazers (20-15) came in with the youngest team in the tournament. They wound up with the program’s first NCAA win since 2005.

The ninth-ranked Cyclones (25-9) came into the South Regional looking for a longer run than a year ago when they reached the Sweet 16. But they couldn’t match the Blazers on the boards in a second half in which the Cyclones couldn’t hold on to a 55-51 lead with 3:13 left.

UCLA 60, SMU 59: Bryce Alford made four 3-pointers in the final 3:40, his last on a rare goaltending call with 13 seconds remaining, to push 11th-seeded UCLA (21-13) to the upset of sixth-seeded SMU (27-7).

Alford’s last attempt was hit by SMU’s Yanick Moreira before it reached the rim. Officials awarded Alford the basket, to the disbelief of the Mustangs.

Sixth-seeded SMU had two shots to win in the final seconds, but Nic Moore missed a 3-pointer and then a 2-point attempt.

UTAH 57, STEPHEN F. AUSTIN 50: Jakob Poeltl had 18 points and eight rebounds, and fifth-seeded Utah (25-8) opened its first tournament appearance in five years by holding off Stephen F. Austin (29-5) at Portland, Oregon.

MIDWEST REGION

NOTRE DAME 69, NORTHEASTERN 65: Zach Auguste scored 25 points, Jerian Grant added 17 and Notre Dame (30-5) dodged a scare at Pittsburgh.

Scott Eatherton had 18 points for 14th-seeded Northeastern (23-12) which gave the Irish fits.

With a chance to tie it at 67 with less than 10 seconds left, Quincy Ford lost control of the ball – and the Huskies lost their upset bid.

BUTLER 56, TEXAS 48: Kellen Dunham scored 20 points, including a pivotal 3-pointer with 1:18 to play, to lift sixth-seeded Butler (23-10) over the Longhorns (20-14).

KENTUCKY 79, HAMPTON 56: Karl-Anthony Towns bounced back from a mini-slump with 21 points and 11 rebounds, Andrew Harrison added 14 points and No. 1 Kentucky (35) rolled past Hampton (17-18) at Louisville, Kentucky.

CINCINNATI 66, PURDUE 65: Troy Caupain got Cincinnati to overtime with his buzzer-beating layup, then Coreontae DeBerry scored four of 13 points in the extra period to help the eighth-seeded Bearcats (23-10) beat Purdue (21-13).

WEST REGION

GEORGIA STATE 57, BAYLOR 56: R.J. Hunter’s 3-pointer with 2.7 seconds remaining capped a comeback from a 12-point deficit and lifted 14th-seeded Georgia State (25-9) over third-seeded Baylor (24-10) at Jacksonville, Florida.

Baylor (24-10) did not score after going up 56-44 on two free throws with 2:54 left. Georgia State forced three turnovers and Hunter shrugged off early poor shooting to score nine straight points.

NORTH CAROLINA 67, HARVARD 65: Justin Jackson hit a tying jumper in the final minute and then had a fast-break dunk to help fourth-seeded North Carolina (25-11) edge 13th-seeded Harvard (22-8) after wasting at 16-point lead.

XAVIER 76, MISSISSIPPI 57: Matt Stainbrook scored 20 points and Dee Davis added 17 for the sixth-seeded Musketeers (22-13) against the Rebels (21-13).

ARKANSAS 56, WOFFORD 53: Michael Qualls scored 20 points, SEC player of the year Bobby Portis added 15 points and 13 rebounds, and fifth-seeded Arkansas (27-8) held off No. 12 seed Wofford (28-7).

ARIZONA 93, TEXAS SOUTHERN 72: Rondae Hollis-Jefferson had 23 points, 16 in the first half, along with 10 rebounds for second-seeded Arizona as the balanced Wildcats (32-3) handled Texas Southern (22-13) at Portland, Oregon.

OHIO STATE 75, VCU 72: D’Angelo Russell scored 28 points and rallied the 10th-seeded Buckeyes (24-10) from an early 12-point deficit for the overtime win over VCU (26-10).

EAST REGION

VILLANOVA 93, LAFAYETTE 52: Dylan Ennis scored 16 points, and Villanova (33-2) thumped Lafayette (20-13) at Pittsburgh, showing why President Obama picked the Wildcats (33-2) to reach the final.

NORTH CAROLINA STATE 66, LSU 65: BeeJay Anya’s hook shot rolled around and in with a second to play, lifting the Wolfpack (21-13) to a stunning win over LSU (22-11) in which they trailed by as many as 16 points.