CHARLOTTE, N.C. – Travis Trice scored 23 points, and Michigan State knocked second-seeded Virginia out of the NCAA men’s basketball tournament for the second straight year, 60-54 on Sunday.

Branden Dawson added 15 points and nine rebounds for the seventh-seeded Spartans, who advanced to the Sweet 16 for the seventh time in the last eight seasons under coach Tom Izzo. The Spartans will play Oklahoma in Syracuse, New York, on Friday in an East Region semifinal.

With top seed Villanova having lost Saturday, it is the first time a No. 1 and 2 seed from the same region didn’t advance to the Sweet 16 since Kentucky and Gonzaga in 2004.

The Spartans stole a page from last year’s regional semifinal win, limiting the Cavaliers to 29.8 percent shooting. Virginia finished 2 of 17 from 3-point range.

Last year, the Spartans upset the top-seeded Cavaliers in the regional semifinal by holding Virginia to 35.1 percent shooting.

The Cavaliers (30-4) were led by Anthony Gill’s 11 points and Darion Atkins’ 10 points and 14 rebounds.

OKLAHOMA 72, DAYTON 66: Jordan Woodard had 16 points and a steal that set up Buddy Hield for a layup to give Oklahoma a lead it never relinquished as the Sooners locked down the Flyers, quieted their fans and advanced to the second weekend of the NCAA Tournament with a victory.

Sooners Coach Lon Kruger became the second coach to take four schools to the round of 16. Third-seeded Oklahoma (24-10) will play Michigan State on Friday at the East Regional in Syracuse, New York.

The Flyers (27-9) came up a victory short of their second straight trip to the Sweet Sixteen as an 11th seed.

LOUISVILLE 66, NORTHERN IOWA 53: Terry Rozier scored 25 points to lift the fourth-seeded Cardinals (26-8) over fifth-seeded Northern Iowa (31-4) in Seattle.

Montrezl Harrell added 14 points for Louisville.

SOUTH REGION

DUKE 68, SAN DIEGO STATE 49: Jahlil Okafor scored 18 of his 26 points in a dominating first half and Duke beat San Diego State, sending the top-seeded Blue Devils back to the Sweet 16.

Fellow freshman Justise Winslow added 13 points and 12 rebounds for Duke (31-4), which for the second straight tournament game ran out to a quick lead and stayed in control the rest of the way.

Duke – holding a No. 1 seed for the 11th time in 18 seasons but its first since 2011 – advanced to face fifth-seeded Utah in Houston’s South Region semifinals.

Mike Krzyzewski’s Blue Devils are pushing for their 12th Final Four and completed their two-game stay in their home state with a pair of hot-shooting wins.

Duke shot 55 percent against the eighth-seeded Aztecs (27-9), two days after shooting 63 percent against Robert Morris.

Fittingly it was Okafor, the big man who has powered Duke’s offense all season, who led the way Sunday.

The 6-foot-11 freshman showed a full range of elite moves in the opening half. He scored with his back to the basket. He put the ball on the floor from about 10 feet and drove for scores. He ran the court for a dunk on a beautiful Cook-to-Jones-to-Okafor push downcourt.

MIDWEST REGION

WICHITA STATE 78, KANSAS 65: No wonder Kansas never wants anything to do with Wichita State.

Behind another steady performance from Fred VanVleet and the hot shooting of Evan Wessel, the No. 7 seed Shockers rolled past the second-seeded Jayhawks, earning a trip to the Sweet 16 at the expense of the school that has caused them so much chagrin.

Tekele Cotton led the way with 19 points for the Shockers (30-4). VanVleet finished with 17 and Wessel hit four 3-pointers to score 12, sending the Missouri Valley champions to Cleveland for the Midwest Regional semifinal against third-seeded Notre Dame.

Devonte’ Graham and Perry Ellis had 17 points each, and Frank Mason added 16 for the Jayhawks (27-9), who blew an early eight-point lead and never really threatened in the second half.

WEST VIRGINIA 69, MARYLAND 59: Devin Williams had 16 points and 10 rebounds and West Virginia pounded the boards for 16 second-chance points to beat fourth-seeded Maryland. Next up: A showdown with top-ranked Kentucky in the Sweet 16.

The fifth-seeded Mountaineers (25-9) will tackle the Wildcats (36-0) at 9:45 p.m. Thursday in the Midwest regional semifinals in Cleveland.

Gary Browne had 14 and Daxter Miles Jr. 12 as West Virginia made it to the regional semis for the first time since 2010, when it went all the way to the Final Four.

WEST REGION

WISCONSIN 72, OREGON 65: Sam Dekker scored 17 points to lead four Wisconsin players in double figures, and the No. 1-seeded Badgers are headed back to the Sweet 16 after defeating Oregon.

The Badgers (33-3) beat the Ducks (26-10) in the round of 32 for the second straight year and will go to Los Angeles to play fourth-seeded North Carolina in the Sweet 16 on Thursday. It’s the fourth time in five years the Badgers made the regional semifinals.

Wisconsin played with the lead all game until Dwayne Benjamin tied it at 52 with a high-arcing 3-pointer from in front of his bench with 5:27 left. The Badgers took the lead right back, though, with Dekker’s reverse layup and 3-pointer to make it 58-52.