STARKVILLE, Miss. — Nick Fitzgerald ran for 182 yards and two touchdowns, Aeris Williams added a career-high 140 yards and Mississippi State upset No. 7 Texas A&M 35-28 on Saturday.

Mississippi State (4-5, 2-3 Southeastern Conference) was coming off an uninspiring 56-41 win over lower-level Samford. The Bulldogs had lost their previous three games against FBS competition.

It was an equally stunning loss for Texas A&M (7-2, 4-2). The Aggies were ranked No. 4 in the first College Football Playoff rankings released Tuesday, but will now almost certainly tumble out of contention.

Mississippi State finished with 365 yards rushing. The Bulldogs’ biggest drive was a grinding 14-play, 73-yard push in the fourth quarter that ended with Fitzgerald running for a 4-yard score for a 35-21 lead.

Texas A&M not only lost the game but possibly its starting quarterback. Trevor Knight left in the second quarter with an apparent right shoulder injury and didn’t return.

(1) ALABAMA 10, (15) LSU 0: Jalen Hurts broke loose for a 21-yard touchdown run to break a scoreless tie early in the fourth quarter, and Alabama’s defense thoroughly stifled Leonard Fournette and LSU in a win at Baton Rouge, Louisiana.

The Crimson Tide (9-0, 6-0 SEC, No. 1 CFP) won for the sixth straight time against LSU (5-3, 3-2, No. 13 CFP), and remained alone in first place in the SEC West.

(2) MICHIGAN 59, MARYLAND 3: Wilton Speight finished with a career-high 362 yards after accounting for three touchdowns in the first half, helping host Michigan (9-0, 6-0 Big Ten, No. 3 CFP) rout Maryland (5-4, 2-4).

The Wolverines scored touchdowns on all five of their drives in the first half.

(3) CLEMSON 54, SYRACUSE 0: Deshaun Watson threw for two touchdowns and ran for a third for host Clemson (9-0, 6-0 Atlantic Coast Conference, No. 2 CFP) before leaving with a bruised shoulder in the Tigers’ rout of Syracuse (4-5, 2-3).

Tigers Coach Dabo Swinney said Watson’s injury wasn’t serious and the team said after halftime that the Heisman Trophy contender could return if needed. With the Tigers up 30-0, it was hardly necessary.

(5) LOUISVILLE 52, BOSTON COLLEGE 7: Lamar Jackson ran for three touchdowns and threw for four more in three quarters to lead Louisville (8-1, 6-1 ACC, No. 7 CFP) past host Boston College (4-5, 1-5).

Tyler Rouse scored from 39 yards out on a screen pass from Patrick Towles to give Boston College (4-5, 1-5) its only score.

(8) WISCONSIN 21, NORTHWESTERN 7: Corey Clement ran for 106 yards and a touchdown, Jazz Peavy scored on a 46-yard run and Wisconsin (7-2, 4-2 Big Ten, No. 8 CFP) beat Northwestern (4-5, 3-3) at Evanston, Illinois.

Conor Sheehy forced a big fumble when he sacked Clayton Thorson with the Wildcats threatening early in the fourth quarter. That led to Clements’ 2-yard TD run that made it a 14-point game.

ARKANSAS 31, (10) FLORIDA 10: Rawleigh Williams ran for 148 yards and two touchdowns to help host Arkansas (6-3, 2-3 SEC) beat Florida (6-2, 4-2, No. 11 CFP) for the first time since 1982.

It was the first SEC victory over the Gators for the Razorbacks. They had lost nine straight to Florida since joining the league in 1992.

(11) AUBURN 23, VANDERBILT 16: Injured Sean White came off the bench to throw a touchdown pass and Josh Holsey intercepted a last-minute throw to lift Auburn (7-2, 5-1 SEC, No. 9 CFP) past visiting Vanderbilt (4-5, 1-4).

The Tigers sputtered after starting John Franklin III in place of White, who had an unspecified injury. White returned to open the second half with Auburn down 13-10, then threw a 21-yard touchdown pass to Darius Slayton and led two field-goal drives.

TCU 62, (13) BAYLOR 22: Kyle Hicks ran for a career-high 192 yards and five touchdowns as TCU (5-4, 3-3 Big 12) dealt Baylor (6-2, 3-2 Big 12, No. 17 CFP) its worst home loss since 2005.

(14) WEST VIRGINIA 48, KANSAS 21: Skyler Howard threw three touchdown passes and ran for two more scores to help West Virginia (7-1, 4-1 Big 12, No. 20 CFP) hand Kansas (1-8, 0-6) its 40th straight road loss.

(18) NORTH CAROLINA 48, GEORGIA TECH 20: Elijah Hood ran for 168 yards and three scores, and host North Carolina (7-2, 5-1 ACC, No. 21 CFP) piled up 636 yards in beating Georgia Tech (5-4, 2-4).

(19) FLORIDA STATE 24, NORTH CAROLINA STATE 20: Deondre Francois threw a 19-yard touchdown pass to Travis Rudolph with 3:09 left to help Florida State (6-3, 3-3 ACC) rally to a win at North Carolina State (4-5, 1-4).