CLEVELAND — The Cleveland Indians can turn their attention back to clinching their division and playoff preparations.

Their historic winning streak is, well, history.

Cleveland had its AL-record run stopped at 22 straight games on Friday night as the Indians were beaten 4-3 by the Kansas City Royals, who became the first team to conquer the defending league champions since Aug. 23.

Jason Vargas (16-10) pitched into the sixth and Brandon Moss homered off Trevor Bauer (16-9) as the Royals ended baseball’s longest winning streak in 101 years. The Indians came within four of matching the overall record held by the 1916 New York Giants.

When Francisco Lindor struck out with a runner on first to end it, the sellout crowd gave the Indians a prolonged standing ovation.

YANKEES 8, ORIOLES 2: Didi Gregorius hit a tiebreaking two-run homer and drove in four runs, leading host New York past Baltimore for its fifth win in six games.

Luis Severino (13-6) allowed two runs on three hits in eight innings with seven strikeouts and a walk.

BLUE JAYS 4, TWINS 3: Josh Donaldson homered and drove in the go-ahead run in the seventh inning with an infield single that ricocheted off the mound, sending Toronto to a win at Minneapolis.

ASTROS 5, MARINERS 2: Carlos Correa and Evan Gattis had two hits apiece and each drove in a run, and Houston cruised at home.

TIGERS 3, WHITE SOX 2: Mikie Mahtook’s game-ending RBI single with two outs in the ninth ended a six-game skid for Detroit.

NATIONAL LEAGUE

DODGERS 7, NATIONALS 0: Alex Wood threw six shutout innings, Corey Seager hit a three-run homer during a five-run second and Los Angeles continued its rebound with a win at Washington.

Wood (15-3) allowed three hits with eight strikeouts and one walk for Los Angeles, which has won three in a row after losing 11 consecutive games and 16 of 17.

CUBS 8, CARDINALS 2: Kris Bryant had three hits, including his 27th homer, and host Chicago overcame the ejections of John Lackey and Willson Contreras in a win at home.

ROCKIES 6, PADRES 1: Tyler Chatwood pitched into the sixth inning and drove in his first runs of the season, Nolan Arenado homered and Colorado won at home.

REDS 4, PIRATES 2: Zack Cozart hit two of Cincinnati’s four solo home runs in a win at home. Joey Votto and Scott Schebler also homer.

BRAVES 3, METS 2: Sean Newcomb recorded eight strikeouts, including five straight, and Atlanta beat visiting New York.

INTERLEAGUE

ATHLETICS 4, PHILLIES 0: Daniel Mengden was dominant in a two-hitter, Matt Olson and Matt Joyce each hit a two-run homer and Oakland won at Philadelphia.