RALEIGH, N.C. — Within hours of announcing its sale to the maker of Budweiser, North Carolina’s beloved Wicked Weed beer lost its voting rights in a craft beer guild, was booted from collaborations with two independent breweries, and exiled from at least a handful of stores and restaurants.

The deal announced Wednesday represents the latest front in the battle between macro- and micro-brewers as behemoths such as Anheuser-Busch Inbev acquire independent brewers to harness the craft segment’s fast growth. Wicked Weed will be one of a dozen brands in Anheuser Busch’s unit called The High End, which includes Breckenridge Brewery in Colorado and Goose Island Brewery in Illinois.

“Our consumers … feel passionate about the brand,” said Walt Dickinson, who co-founded Wicked Weed in 2012. “I’m respectful of their feelings. It’s going to be our job going forward to win them back and show them that we’re the exact same people.”

Other well-known craft brewery acquisitions include the purchase of California’s Ballast Point by Constellation Brands, and Molson Coors owns stakes in smaller brewers such as Georgia’s Terrapin Beer Co.

However, craft beer lovers seemed to take the sale of Wicked Weed harder than other recent deals, judging from scores of social media comments, said Paul Gatza, director of the Brewers Association trade group. He believes that could be because of Wicked Weed’s reputation for creativity, particularly sour beers.

“This one seems to have really struck a nerve, more so than some of the previous acquisitions,” he said.

Dickinson said other companies were interested in buying Wicked Weed, but Anheuser Busch offered the best opportunity for the brewery to maintain a high level of autonomy.

“I could name 10 other partners we could have chosen besides The High End that the beer industry would have had a lot better feelings about, but at the end of the day I believe this was the right choice for our brand and our company,” he said.

The deal, subject to regulatory approval, will make Wicked Weed a subsidiary owned outright by Anheuser Busch Inbev, said Adam Warrington, a spokesman for The High End unit. Terms of the deal were not released.

At the bar at House of Hops in Raleigh, 34-year-old Robert Royster said the sale will be a deterrent. “It really feels like they are trying to monopolize things for profits and not for taste,” Royster said of Anheuser Busch.

The Wicked Weed news drew scores of comments online. Many people decried the sale, while others said they intended to keep drinking the brand’s flavors, which include Pernicious IPA and Lunatic Blonde.

The North Carolina Craft Brewers Guild announced that the Asheville brewer would no longer be a voting member, saying it was “disheartened” by the sale. Craft brewers Jester King Brewery in Texas and Black Project Spontaneous & Wild Ales in Colorado said they were backing out of joint projects with Wicked Weed.

“We truly believe that ABinBev intends to systematically destroy American craft beer as we know it,” Black Project’s James and Sarah Howat said in a blog post.

Brawley’s Beverage in Charlotte was among the stores and restaurants that said they would stop selling Wicked Weed.

“If we continue to buy those brands, then we tacitly approve of Budweiser’s attempt to buy out their competition and use that competition by dropping the prices to hammer my friends’ brewery,” owner Michael Brawley said. “We don’t have a choice.”