LOS ANGELES — Brad Grey, an influential Hollywood leader who served as chairman and CEO of Paramount Pictures for 12 years, has died.

A family spokeswoman said Monday that Grey, who was battling cancer, died Sunday at his home in Los Angeles. He was 59.

Before exiting Paramount in February, Grey oversaw franchises such as “Star Trek,” “Transformers” and “Mission: Impossible,” prestige properties like “There Will Be Blood,” “No Country for Old Men,” “Up in the Air,” “The Big Short,” “The Curious Case of Benjamin Button” and “Babel,” and multiple films from Martin Scorsese including “The Wolf of Wall Street,” “Shutter Island” and “Hugo.”

Grey also produced Scorsese’s “The Departed,” which won Best Picture in 2007.

During his storied career in the entertainment business, Grey founded the management and production company Brillstein-Grey Entertainment with the late Bernie Brillstein, co-founded the production company Plan B Entertainment with Brad Pitt and Jennifer Aniston, and produced multiple Emmy Award-winning television shows, including “The Sopranos,” “Real Time with Bill Maher” and “The Larry Sanders Show.”

His Hollywood peers and colleagues offered their remembrances Monday.

Director Ava DuVernay, who worked with Grey on “Selma,” wrote on Twitter that she had dinner with him prior to the film’s release.

“Fab stories. Good laughs. And shrewd advice that I still use,” DuVernay wrote. “May his soul be at rest.”

“G.I. Joe: Retaliation” director John Chu called Grey “A really good man. Kind & classy and a helluva boss.”

“Oh man the world has lost a gentleman,” Chu wrote on Twitter.

Current Paramount Pictures CEO Jim Gianopulos also released a statement Monday.

“All of us at Paramount are deeply saddened by the news of Brad Grey’s passing,” Gianopulos said. “I was proud to call Brad a friend, and one I greatly admired. He will be missed by us all, and left his mark on our industry and in our hearts.”

Viacom President and CEO Bob Bakish said he was “An extraordinary talent with a passion and gift for storytelling that won’t be forgotten.”

Sumner and Shari Redstone, in a joint statement, noted how Grey’s “tremendous kindness and talent inspired so many of us in the entertainment industry.”

“As a producer and industry leader, Brad brought great storytelling to audiences around the world,” added MPAA Chairman and CEO Chris Dodd in a statement. “His contributions to the creative community will be enjoyed for years to come.”

Among his achievements at Paramount, Grey was at the helm for the release of the top-grossing film in the studio’s history, “Transformers: Dark of the Moon,” led the acquisition of DreamWorks SKG, and shepherded the distribution agreement with Marvel, releasing “Iron Man, “Iron Man 2,” “Thor” and “Captain America” before The Walt Disney Company acquired Marvel Studios in 2009.

Born in New York in 1957, Grey started out in the entertainment business as an assistant to Harvey Weinstein, who was then a concert promoter. His first client was comedian Bob Saget, and his partnership with comics, including the late Garry Shandling, helped make his name in the business.

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