BOSTON — Chris Sale struck out eight over 42/3 innings in his final tuneup for an expected start in the AL Division Series opener before the Baltimore Orioles salvaged a split of Wednesday’s day-night doubleheader with a 10-3 victory over the Boston Red Sox.

Boston won the opener 19-3, dealing the Orioles a franchise-record 112th loss. The Red Sox were 16-3 against Baltimore this year.

A major league-best 107-52, Boston opens the Division Series at home Oct. 5 against the New York Yankees or Oakland.

Sale left after giving up Adam Jones’ go-ahead, RBI double that made it 3-2 in the fifth. He threw 92 pitches, allowing three runs and four hits.

Sale was limited to one start in six weeks because of left shoulder inflammation but has gradually built up his pitch count in four outings. He had control trouble early, hitting two batters on sliders in the first inning as he allowed two runs.

Trey Mancini had a tie-breaking two-run single off Matt Barnes (6-4) in a three-run seventh and drove in three runs. Tanner Scott (3-2) worked 22/3 innings of one-run relief, and Paul Fry pitched three hitless innings for his second save.

In the opener, J.D. Martinez had three of Boston’s season-high 22 hits, including a three-run homer that brought his major league-leading RBI total to 127. The Orioles (46-112) broke the franchise loss mark set by the 1939 St. Louis Browns went 43-111.

“Man, he doesn’t leave anyone for no one,” Xander Bogaerts said in mock anger after driving in four runs to reach 100 RBI for the first time in his career and lead Boston to a big win.

The Red Sox had five homers and nine doubles and matched their biggest scoring output this season. The 14 extra-base hits were the most in the majors this year and the most for Boston since 1950.

In the makeup of Tuesday’s rainout, David Price (16-7) settled down after an early stumble in his final start before the playoffs. He allowed three runs – all in the second inning – six hits and three walks, striking out six before leaving with a 10-3 lead after five.

“Probably I was one pitch from getting taken out of that game,” said Price, who is expected to start Game 2 of the AL Division Series. “To reel it back in … was big.”

Rafael Devers had four hits and six RBI, including two homers, and Mookie Betts had two hits to raise his major league-best batting average to .346. Betts also stole a base, making him the second player in Red Sox history with at least 30 homers and 30 stolen bases in a season. Jacoby Ellsbury, who had 32 homers and 39 steals in 2011, is the only other member of Boston’s 30-30 club.

Ryan Meisinger (2-1) got just one out in his first start since he was a sophomore at Radford University, allowing five runs and four hits.

NOTES: TV color analyst Jerry Remy visited the booth and was on the air briefly because “he wanted to thank the fans” for the cards and letters as he undergoes cancer treatment again. Remy, 65, has had numerous reoccurrences with the disease. He was first diagnosed with lung cancer in 2008. He plans to return in a limited role next season. “I think the best way to describe it is: I’m not retiring,” he said. “But, they’ll be limitations. I’m not going to travel anymore.” … INF Eduardo Nunez, who hasn’t played since Sept. 19 due to hamstring soreness, ran in the outfield with a team athletic trainer watching between games. Manager Alex Cora said he’ll DH Friday and play third on Sunday.

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