HOUSTON — Aaron Sanchez looked like a reinvented pitcher in his Houston debut, throwing six stellar innings to start the Astros on a combined no-hitter Saturday night in a 9-0 victory against the Seattle Mariners.

Sanchez was an All-Star in 2016 and led the American League in ERA, but struggled this season and had lost 13 straight decisions to lead the majors with 14 losses. But three days after he was acquired from Toronto at the trade deadline, he teamed with Will Harris, Joe Biagini and Chris Devenski to shut down the Mariners.

It was the second time in less than a month the Mariners were no-hit by multiple pitchers. The Angels used two pitchers in a combined no-hitter July 12 against Seattle on the night they honored the late Tyler Skaggs by all wearing his No. 45 in their first home game since his death.

Mike Fiers pitched the previous no-hitter for Houston against the Los Angeles Dodgers on Aug. 21, 2015.

NATIONAL LEAGUE

CUBS 4, BREWERS 1: Cole Hamels pitched five shutout innings after spending five weeks on the injured list, Albert Almora Jr. hit a tiebreaking home run and Chicago won at home.

Out since June 28 because of a strained left oblique, Hamels allowed four singles, walked none and struck out six.

METS 7, PIRATES 5: Wilson Ramos hit a go-ahead two-run home run in the eighth inning and added a three-run double in the ninth to lift New York at Pittsburgh.

Marcus Stroman, acquired by New York in a trade with Toronto last Sunday, allowed three runs on seven hits in 4 1/3 sometimes shaky innings but received a no-decision when the Mets pounced on Pittsburgh’s bullpen.

PHILLIES 3, WHITE SOX 2: Aaron Nola pitched seven strong innings, Bryce Harper and Rhys Hoskins homered, and Philadelphia won at home.

Nola (10-2) allowed one run and three hits with 10 strikeouts and two walks. He lowered his ERA to 1.91 over his last eight starts while reaching double-digits in strikeouts for the 12th time in his career, including the fourth this season.

INTERLEAGUE

RAYS 8, MARLINS 6: Eric Sogard homered twice and finished with a career-high five RBI, and Tampa Bay won at St. Petersburg, Florida.

Willy Adames and Austin Meadows also connected as Tampa Bay won for the seventh time in eight games. Nick Anderson (3-4), who was acquired Wednesday in a trade with Miami, pitched a perfect eighth for the win, and Emilio Pagan finished for his ninth save.

NOTES

ATHLETICS: Oakland activated outfielder Stephen Piscotty from the injured list and claimed catcher Dustin Garneau off waivers from the Los Angeles Angels.

Piscotty had been out since June 30 with a sprained right knee. He played five games in the minors while rehabbing, and batted .304 with one home run and three RBI.

CUBS: Catcher Willson Contreras left the game with Milwaukee in the seventh inning with an apparent hamstring injury. He was replaced behind the plate by Victor Caratini.

Contreras pulled up and grabbed the back of his right leg as he exited the batter’s box after hitting the ball to right-center off Junior Guerra to lead off the inning. Brewers center fielder Lorenzo Cain made a nifty running catch to retire Contreras.

ROCKIES: Colorado placed outfielder David Dahl on the 10-day injured list with a high right ankle sprain.

An MRI confirmed the injury, which occurred during the sixth inning of Friday night’s victory against San Francisco.

TWINS: Minnesota put often-injured center fielder Byron Buxton and pitcher Michael Pineda on the 10-day injured list.

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