Giants running back Saquon Barkley (26) celebrates his touchdown in overtime that gave New York at 27-21 win over the Saints on Sunday in New Orleans. Brett Duke/Associated Press

NEW ORLEANS — Saquon Barkley ran for a 6-yard touchdown in overtime after Daniel Jones passed for a career-high 402 yards, and the New York Giants rallied for their first win of the season, 27-21 over the New Orleans Saints on Sunday.

The Saints, playing in New Orleans for the first time since Hurricane Ida struck on Aug. 29, led 21-10 in the fourth quarter before Jones and Barkley combined for a 54-yard touchdown pass that ignited the Giants’ comeback.

Jones ran for a 2-point conversion to make it 21-18, then led the Giants to Graham Gano’s tying, 48-yard field goal with 31 seconds left in regulation.

After New York won the coin toss to start the extra period, Jones completed five passes for 67 yards to set up Barkley’s winning score, giving the Giants (1-3) a last-play victory for a change after they’d lost on game-ending field goals the previous two weeks.

JETS 27, TITANS 24: Matt Ammendola kicked a 22-yard field goal in overtime, and then Randy Bullock was wide left on a potential tying 49-yarder with 15 seconds left to give New York its first victory, in East Rutherford, New Jersey.

After the Jets took the lead in the extra period but failed to seal it with a touchdown despite getting to the 1-yard line, Ryan Tannehill – playing without injured receivers Julio Jones and A.J. Brown – marched the Titans downfield with the help of two fourth-down conversions.

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On second-and-5 from the Jets 26, Anthony Firkser couldn’t hold onto a pass from Tannehill and then the Titans took a delay of game penalty. Tannehill threw incomplete to Jeremy McNichols, setting up the tying kick for Bullock – but the ball sailed wide of the left upright and sent the Jets (1-3) into a wild celebration.

Coach Robert Saleh got his first win as a head coach, getting a Gatorade shower on the sideline from Ryan Griffin.

BILLS 40, TEXANS 0: Linebacker Tremaine Edmunds had the first of Buffalo’s four interceptions, and the Bills suffocated offensively inept Houston for a win in Orchard Park, New York.

Micah Hyde, Tyler Matakevich and Jaquan Johnson, in his first career start, each had interceptions, while Cam Lewis forced a fumble as Buffalo overwhelmed rookie quarterback Davis Mills in his second career start.

The Bills limited Houston to 109 yards of offense – 8 in the first half – and six first downs to post their second shutout in three weeks. Buffalo, which blanked Miami 35-0 on Sept. 19, has two shutouts in a season for the first time since 1990.

Josh Allen finished 20 of 29 for 248 yards with two touchdowns – a 25-yarder and a 1-yarder, both to Dawson Knox – and an interception before giving way to backup Mitchell Trubisky with 8:03 remaining.

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CARDINALS 37, RAMS 20: Kyler Murray passed for 268 yards and two touchdowns and ran for 39 more yards in a virtuoso performance, and Arizona extended its longest unbeaten start since 2012 with a victory over Los Angeles in Inglewood, California.

A.J. Green caught a 41-yard TD pass, Chase Edmonds ran for 120 yards and James Conner rushed for two short scores for Arizona (4-0), which finally beat Sean McVay for the first time in nine tries.

Kliff Kingsbury’s Cards did it with style, lighting up the Rams’ defense for 465 total yards and scoring touchdowns after two early takeaways to affirm their arrival as a contender in the NFC West and beyond despite playing three of their first four games on the road.

Maxx Williams caught a TD pass from Murray, who went 24 for 32 and repeatedly frustrated the Rams’ defense. Arizona’s defense made several big plays, and it sealed the team’s first victory over the Rams since Jan. 1, 2017, by stopping Matthew Stafford and the LA offense on downs at the 1 with 12:05 to play.

Stafford went 26 of 41 for 280 yards and two touchdowns in his first ineffective performance with the Rams (3-1), who failed to start 4-0 for the first time since 2018 with an ugly home performance.

CHIEFS 42, EAGLES 30: Patrick Mahomes threw five touchdown passes three different ways, including three to Tyreek Hill, and Kansas City won in Philadelphia.

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Andy Reid returned to Philadelphia and earned his 100th career win with the Chiefs, becoming the first coach in NFL history to win 100 games with two teams. Reid’s 140 victories with the Eagles are the most in franchise history.

Jalen Hurts threw for a career-high 387 yards and two TDs but Philadelphia (1-3) couldn’t keep up with Kansas City’s high-powered offense. The Eagles had three touchdowns negated by penalty and settled for field goals three times inside the red zone.

The two-time defending AFC champion Chiefs (2-2) snapped a two-game losing streak after entering with a losing record for the first time since they were 4-5 in 2015.

COWBOYS 36, PANTHERS 28: Dak Prescott threw four touchdown passes, Ezekiel Elliott had his first 100-yard rushing game of the season against the NFL’s No. 1 defense and host Dallas beat Carolina.

Elliott finished with 143 yards and a touchdown on 20 carries as the Cowboys (3-1) rolled up 245 yards on the ground after the Panthers allowed just 135 total in the first three games.

Leading the Panthers in their first full game without injured star running back Christian McCaffrey, Sam Darnold had two rushing touchdowns to become the first quarterback in NFL history with at least five TDs on the ground in the first four games.

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COLTS 27, DOLPHINS 17: Carson Wentz threw a pair of touchdown passes to Mo Alie-Cox, Jonathan Taylor rushed for 103 yards and a score and Indianapolis got its first win of the season by winning in Miami Gardens, Florida.

Wentz completed 24 of 32 passes for 228 yards for the Colts (1-3), who avoided what would have been their first 0-4 start since 2011. They spent most of the day frustrating former Indianapolis quarterback Jacoby Brissett, who completed 20 of 30 passes but threw for 123 of his 199 yards in the final quarter.

It was the first two-TD game for Alie-Cox, who had a total of four scores in his first 43 NFL appearances entering Sunday.

BEARS 24, LIONS 14: Rookie Justin Fields brushed off a nightmarish first start, and Chicago bounced back from one of the worst offensive performances the NFL has seen to beat the winless Detroit in Chicago.

Fields and the Bears (2-2) were in much better form coming off a brutal loss at Cleveland last week. They rang up 373 yards after being held by the Browns to 47, the ninth-lowest total in league history.

Fields looked more comfortable, completing 11 of 17 passes for 209 yards and an interception in his second consecutive start with Andy Dalton sidelined because of a bone bruise in his left knee. The No. 11 overall draft pick was sacked just once, after being taken down nine times for 67 yards while throwing for just 68 the previous week.

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BROWNS 14, VIKINGS 7: Myles Garrett and the Cleveland defense produced another dominant performance, giving Coach Kevin Stefanski a victory over his old team as the Browns won in Minneapolis.

Garrett was credited with one-half of Cleveland’s two sacks and four hits on Kirk Cousins, Greedy Williams became the first player this season to intercept Minnesota’s quarterback and the Browns (3-1) again leaned on their two-pronged rushing attack with predictable success.

Kirk Cousins hit Justin Jefferson for a touchdown pass to cap a commanding opening drive by the Vikings (1-3), who took possession 11 more times without scoring or even trying a field goal. The furthest they came was the 26-yard line, where they had one final play to tie the game. Cousins threw on the run into the end zone, where the ball fell incomplete.

WASHINGTON 34, FALCONS 30: Taylor Heinicke ad-libbed a 30-yard touchdown pass to J.D. McKissic with 33 seconds remaining, rallying Washington  to a victory in Atlanta.

Returning to the metro area where he grew up, Heinicke completed 23 of 33 passes for 290 yards and three touchdowns — two of them in the final 3:52 to pull it out for Washington (2-2).

SEAHAWKS 28, 49ERS 21: Russell Wilson overcame a shaky start to throw for two touchdowns and run for a third and Seattle rebounded from back-to-back losses by beating San Francisco in Santa Clara, California.

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The Seahawks (2-2) went three-and-out on their first five drives of the game and appeared in danger of their first three-game losing streak in a season in nine seasons with Wilson at quarterback.

But he connected on a 12-yard TD pass to DK Metcalf late in the first half and then produced two touchdowns in a span of less than a minute in the third quarter with a 16-yard run and 13-yard pass to Freddie Swain around a fumbled kickoff by Trenton Cannon.

The TD pass to Swain was vintage Wilson, who spun away from a blitzing Dontae Johnson before finding Swain for the TD.

RAVENS 23, BRONCOS 7: Lamar Jackson threw for 316 yards, including a 49-yard touchdown pass to a diving Marquis Brown, and Baltimore used a relentless defense to swat Denver from the ranks of the unbeaten with a win in Denver.

The Ravens (3-1) won their third consecutive game following an overtime loss to Las Vegas in the opener. They were in danger of coming up just short of tying the Steelers’ NFL record for consecutive games with at least 100 yards rushing before Baltimore cornerback Anthony Averett intercepted Drew Lock in the end zone with 3 seconds left.

Instead of taking a knee in victory formation, Jackson took the shotgun snap from his 20 and hustled around left end for a 5-yard gain. That gave the Ravens 102 yards on the ground, their 43rd consecutive 100-yard rushing game, which tied the mark set by Pittsburgh from 1974-77.

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The Ravens knocked Broncos starting quarterback Teddy Bridgewater from the game with a concussion on his final pass of the first half. Rookie linebacker Odafe Oweh wasn’t flagged for hitting Bridgewater in the chin.

PACKERS 27, STEELERS 17: Aaron Rodgers connected with Randall Cobb for two touchdowns and ran for another score as Green Bay won its third straight, beating Pittsburgh in Green Bay, Wisconsin.

Cobb caught a 23-yard touchdown pass in the second quarter to put the Packers (3-1) ahead for good and scored again on a 1-yard reception that made it 27-10 in the third period. That short throw was the 420th TD pass of Rodgers’ career, tying Dan Marino for sixth all-time.

Rodgers went 20 of 36 for 248 yards and scored the Packers’ first points on a 4-yard rush in his first home start against the Steelers, the only team he hadn’t faced at Lambeau Field.

Pittsburgh (1-3) has lost three straight, failing to top 17 points in each game, since a surprising season-opening win at Buffalo.

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