CHICAGO — David Price felt healthy and strong. Dustin Pedroia had a swollen left wrist after an awkward tumble.

Reasons for hope and concern for the Red Sox.

Price lasted five innings in his season debut in Boston’s 5-4 loss to the Chicago White Sox on Monday, but the left-hander’s encouraging outing took a back seat to another injury for a key teammate.

Pedroia bounced to first in the first inning and Jose Abreu slid into the bag for the out. Pedroia went right over the top of the big first baseman while trying to beat out the grounder for a hit, putting his hands on the ground to brace for the fall .

The Red Sox then pulled Pedroia in the second with a sprained wrist, and Manager John Farrell said the 2008 AL MVP was headed back to Boston for tests.

“It’s hard to say right now, and I think until we get the information, we’ll know more then,” Farrell said. “But I think anytime you’re dealing with a position player’s wrist, a hitter’s wrist, that’s always cause for concern.”

Melky Cabrera homered and drove in four runs for the White Sox, who rallied for their fourth win in five games. Juan Minaya (1-0) and Tommy Kahnle each pitched a scoreless inning before David Robertson earned his eighth save in nine chances.

Price, who missed the first part of the year with a strained left elbow, walked two, hit two batters and surrendered Cabrera’s three-run homer in the third. But the 2012 AL Cy Young Award winner allowed just two hits and struck out four while throwing 88 pitches, 58 for strikes.

“It’s definitely a step in the right direction,” said Price, in the second season of a $217 million, seven-year contact. “I felt good. Just command the baseball a little bit better with my fastball and I think things will take off for me.”

NOTES: Pablo Sandoval (sprained right knee) remains on a rehab assignment at Triple-A Pawtucket, and Farrell said they will take a look “where things are” with the third baseman after the series against the White Sox. … RHP Carson Smith (Tommy John surgery) threw a bullpen session Sunday and is scheduled for another one on Tuesday.