Cleveland center Jarrett Allen shoots over Boston’s Kristaps Porzingis during Tuesday’s game in Cleveland. Sue Ogrocki/Associated Press

CLEVELAND — Dean Wade made five 3-pointers and scored 20 points in the fourth quarter, and Cleveland won a replay review in the final second to stun Boston 105-104 on Tuesday night, ending the NBA-leading Celtics’ winning streak at 11 games.

The Cavs overcame a 22-point deficit in the fourth quarter. They did it without All-Star Donovan Mitchell, who missed the game with a knee injury, as well as forward Evan Mobley, who went out with a sprained ankle in the third quarter.

Wade, who finished with a career-high 23 points, came to the rescue with his barrage of 3s and a putback dunk with 19.1 seconds left that put the Cavs ahead 105-104. He personally outscored the Celtics 20-17 in the fourth.

The Celtics looked for a final shot and All-Star Jayson Tatum, who led Boston with 26 points, appeared to draw a foul on Darius Garland while shooting a fadeaway jumper with 0.7 seconds left.

The Cavs challenged the call, and following the review, officials said it was Tatum’s leg that caused the contact and not Garland.

It was the latest stirring win at home for the Cavs, who beat Dallas last week on Max Strus’s 60-foot shot at the buzzer.

Jarrett Allen added 21 points and Darius Garland 16 with 11 assists for the Cavs, who made eight of 11 3-pointers in the fourth. Reserve Georges Niang also made two big 3s in Cleveland’s rally.

Kristaps Porzingis scored 24 points and Jaylen Brown had 21 for Boston, which lost for the first time since Feb. 1. The Celtics won three times by more than 40 points in that stretch.

Mitchell, the Cavs’ leading scorer, has a left knee injury. He’ll miss at least the next two games, and he could be out longer with an injury that wasn’t responding to rest. Mitchell received a platelet-rich plasma injection on Monday. He’ll be re-examined this weekend.

Cleveland also lost Mobley, who didn’t return after spraining his left ankle with 5:29 left in the third quarter.

The Celtics were coming off a 52-point blowout of Golden State, the club’s third win by 50 or more this season. They were still comfortably up by 16 with 7:28 left, but the Cavs kept chipping away before and Wade finally put them ahead with his fifth 3.

NOTES: NFL star Travis Kelce urged on Cleveland’s crowd from a courtside seat. Kelce attended the game with his brother, Jason, as the Cavs gave away a bobblehead depicting the Cleveland-born NFL stars. Jason Kelce, who retired from the Philadelphia Eagles after 13 seasons on Monday, was presented with a No. 62 jersey.