Emergency services assess a building hit by an air strike in Damascus, Syria, on Monday. Israel has been targeting Iranian officers in Syria and in Lebanon as Iran provides money and weapons to Hezbollah, as well as Hamas and other Palestinian militant groups. Omar Sanadiki/Associated Press

TEHRAN, Iran — Iran on Tuesday vowed to respond to an airstrike widely attributed to Israel that destroyed Iran’s Consulate in the Syrian capital of Damascus the previous day and killed 12 people, including two Iranian generals and a member of the Lebanese militant Hezbollah group.

Four Syrian citizens were also killed in the strike, a Syrian official said Tuesday, without providing any details about them. Hezbollah, which has been a key ally of both Syrian President Bashar Assad’s government and Iran, also pledged “punishment and revenge” on Israel.

Israel, which has repeatedly targeted Iranian officers in Syria and in Lebanon, did not confirm Monday’s attack.

Iran provides money and weapons to Hezbollah, as well as Hamas and other Palestinian militant groups fighting Israel in Gaza. Clashes between Israel and Hezbollah along the Israeli-Lebanese border have increased since the war in Gaza began nearly six months ago.

Iran’s Supreme National Security Council, a key decision-making body, met late on Monday and decided on a “required” response to the strike, Iran’s state television reported. It said the meeting was chaired by President Ebrahim Raisi but provided no further details.

“We will make them regretful about the crime and similar acts,” said Supreme Leader Ayatollah Ali Khamenei, who has final say on all state matters in Iran.

The U.S. National Security Council said the United States played no role in the strike in Damascus and did not know of it ahead of time. Americans directly advised Iran of that, a U.S. official said, speaking on condition of anonymity to discuss the matter.

It was not clear if and when Iran would respond, but any retaliation from Tehran would risk a dangerous confrontation with Israel and the U.S.

Later Tuesday, Assad expressed his condolences in a telephone call with Raisi and condemned Israel, Syrian state news agency SANA reported.

The airstrike killed Gen. Mohammad Reza Zahedi, who led the Iranian Revolutionary Guard’s Quds Force in Lebanon and Syria until 2016, his deputy, Gen Mohammad Hadi Hajriahimi, and five other officers. A member of Hezbollah, Hussein Youssef, also was killed in the attack.

Syrian Health Minister Hassan al-Ghabash said that along with the four Syrian nationals killed, 13 others were seriously wounded in the airstrike. He also did not disclose any information about the wounded.

The Britain-based Syrian Observatory for Human Rights, a war monitoring group, said the Syrians were members of pro-Iran militias but didn’t elaborate.

In announcing Youssef’s death, Hezbollah also did not provide any details about him on Tuesday. It said Zahedi played a crucial role in helping “develop and advance the work” of the group in Lebanon.

“This crime will certainly not pass without the enemy receiving punishment and revenge,” the Hezbollah statement said.

Syrian Prime Minister Hussein Arnous, after visiting the Iranian Embassy in Damascus, said rescue workers are still searching for bodies under the rubble of the consulate building.

Since the Oct. 7 outbreak of the Gaza war, Iran’s proxies have stepped up attacks, with near-daily cross-border exchanges between Hezbollah and Israel, and frequent attacks on Red Sea shipping by Yemen’s Iran-backed Houthi rebels.

Israel, which rarely acknowledges strikes against Iranian targets, said it had no comment on the latest attack in Syria, although a military spokesman blamed Iran for a drone attack early Monday against a naval base in southern Israel.

Emergency service workers clear the rubble at a destroyed building struck by Israeli jets in Damascus, Syria, on Monday. SANA via AP

Israel, increasingly impatient with the exchanges with Hezbollah, has warned of the possibility of a full-fledged war. The Houthis have also been launching long-range missiles toward Israel, including on Monday.

Israeli Defense Minister Yoav Gallant said the country is in a war on multiple fronts “both offensively and defensively.”

“We see evidence of this every day, including over the last few days,” said Gallant, speaking to the Israeli parliament’s Defense and Foreign Affairs Committee. “We operate everywhere, every day, in order to prevent our enemies from gaining strength and in order to make it clear to anyone who acts against us – all over the Middle East – that the price for action against Israel will be a heavy one.”

U.N. Secretary-General António Guterres condemned the strike on the Iranian Consulate and reaffirmed on Tuesday “the principle of the inviolability of diplomatic and consular premises,” according to his spokesman Stephane Dujarric. Guterres also said diplomatic personnel “must be respected in all cases in accordance with international law.”

The U.N. Security Council scheduled an emergency meeting on Tuesday at Tehran’s request.

Gulf monarchies Saudi Arabia, the United Arab Emirates and Qatar condemned the strike as fears grow of a widening regional conflict. The 22-state Arab League slammed Israel, saying it aims to “expand the war and push the region to chaos.”

Iran’s official news agency IRNA said Iran relayed an important message to the U.S. late Monday, delivered through a Swiss envoy in Tehran. Switzerland looks after U.S. interests in Iran as Washington and Tehran have no diplomatic relations.

IRNA also said Iran holds the U.S., Israel’s closest ally, responsible for the strike.

Meanwhile, a U.S. defense official said that an attack drone was detected and destroyed by U.S. forces at Al-Tanf Garrison in Syria on Monday afternoon.

No injuries and no damage to infrastructure were reported. The official spoke on the condition of anonymity to discuss details not yet made public. The drone was in the vicinity of the base, but it was not clear whether it was targeting the base, the official said.

And in the Red Sea, the U.S. Central Command said early Tuesday that its forces destroyed a Houthi unmanned surface vessel the previous day. CENTCOM said the vessel posed “a threat to U.S. and coalition forces and merchant vessels in the region.”