BOSTON — Franklin Gutierrez is developing an affinity for Fenway Park.

Gutierrez homered in his first two at-bats and drove in a career-high six runs Friday night as the Seattle Mariners outslugged the Boston Red Sox, 8-4.

Seattle's Ketel Marte slides past Red Sox catcher Sandy Leon to score on a double by Franklin Gutierrez during the fourth inning of Friday's game at Fenway Park. The Mariners won, 8-4. The Associated Press

Roenis Elias underwent a 30-pitch first inning Friday night for the Boston Red Sox and was the loser in an 8-4 loss to Seattle. Elias was sent down after the game.

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WHO: Seattle Mariners (TBD) at Boston Red Sox (Rick Porcello 7-2)

WHEN: 4:05 p.m. Saturday

TELEVISION: NESN

It was the third multi-homer game in Gutierrez’s career and first since he hit a pair in Boston last August.

“So I guess I see the ball pretty good here at Fenway Park,” said Gutierrez, who also doubled with the bases loaded as the Mariners scored the first seven runs of the game. “It’s a good day today. What can I say?”

Robinson Cano drove in Seattle’s other two runs, including his 19th homer with a leadoff shot in the seventh, as Seattle won its second straight since a four-game losing streak.

David Ortiz hit a two-run homer for Boston in the fourth. It was the 521st homer for Ortiz, tying him with Red Sox great Ted Williams, Willie McCovey and Frank Thomas for 19th on the career list.

Not easily humbled, Ortiz spoke reverently about the company he joined Friday night.

“It means a lot. Historically, you guys know how great Mr. Ted Williams was,” Ortiz said. “It’s wonderful, man. We’re talking about some of the greatest hitters in the game.”

Ortiz’s shot to center off Hisashi Iwakuma cut Seattle’s lead to 7-2 in the fourth. After Cano’s homer in the seventh, the Red Sox added two more runs in the bottom half of the inning but couldn’t overcome their early deficit.

Iwakuma (6-5) went seven innings, allowing four runs on nine hits. Iwakuma pitched deep enough to keep Seattle from stressing its bullpen too much on a day the Mariners lost another starter to the disabled list.

Wade Miley, scheduled to start Saturday, joined Felix Hernandez on the DL earlier Friday.

“It’s one of the better hitting teams in the league, so I tip my hat to Kuma,” Seattle Manager Scott Servais said.

“It was huge, especially with the spot starter coming tomorrow. We really needed that to kind of calm things down here a bit.”

Steve Cishek came in to end a threat by Boston in the ninth and picked up his 16th save.

The Mariners roughed up former teammate Roenis Elias (0-1) early in his first start for Boston, which acquired him in an offseason deal with Seattle. Elias threw 30 pitches in the first inning and was down 2-0 after just three of them.

Ketel Marte singled on the opening pitch, then Gutierrez hit a 1-0 change-up out to center for his sixth homer of the season.

Gutierrez led off the third with a shot to left that cleared the Green Monster and everything above it, then just missed a grand slam in the fourth with a three-run double to the base of the right-field wall that gave the Mariners a 6-0 lead.

NOTES: The Red Sox announced after the game that Elias and outfielder Rusney Castillo were returning to Triple-A Pawtucket and that Clay Buchholz, who had been banished to the bullpen, would return to the starting rotation and pitch Wednesday.

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